ArticleNature neuroscience2023
A stable and replicable neural signature of lifespan adversity in the adult brain.
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Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
19.1field-weighted citation impact, top 1% of its field
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Who cites it
30 citing papers in PubMed, 61 citations in OpenAlex.
- Adversity and adolescent brain development: differential associations with grey and white matter across two longitudinal cohorts.bioRxiv : the preprint server for biology · 2026Article
- Impact of adverse life experiences on pain, depression, anxiety, and comorbidities: a youth longitudinal sample.Pain reports · 2026Article
- The influence of sample size and covariate distributions on neuroanatomical normative modeling.eLife · 2026Article
- Persistent structural alteration of the extended limbic system in adolescents with childhood maltreatment.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Article
- Early Life Adversity and Disordered Eating: Cognitive and Neural Mechanisms.Behavioral sciences (Basel, Switzerland) · 2025Review
- Understanding individual neurodegenerative progression in Parkinson's disease through normative modelling.Scientific reports · 2025Article
- Reconfiguration of brain-wide neural activity after early life adversity.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Early adversity alters brain architecture and increases susceptibility to mental health disorders.Nature reviews. Neuroscience · 2025Review
- Neural correlates of human fear conditioning and sources of variability in 2199 individuals.Nature communications · 2025Article
- Reconfiguration of brain-wide neural activity after early life adversity.bioRxiv : the preprint server for biology · 2025Article
- Trauma-predictive brain network connectivity adaptively responds to mild acute stress.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Neuroimaging stratification reveals the striatal vulnerability to stress as a risk for schizophrenia.Translational psychiatry · 2025Article
- Spectral normative modeling of brain structure.medRxiv : the preprint server for health sciences · 2025Article
- Semantic search helper: A tool based on the use of embeddings in multi-item questionnaires as a harmonization opportunity for merging large datasets - A feasibility study.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- A multimodal neural signature of face processing in autism within the fusiform gyrus.Nature. Mental health · 2025Article
- Towards closed-loop precision psychiatry: Integrating MRI biomarkers for individualized care of major depressive disorder.Psychoradiology · 2025Review
- Complement and microglia activation mediate stress-induced synapse loss in layer 2/3 of the medial prefrontal cortex in male mice.Nature communications · 2024Article
- Effects of lockdowns in shaping socioeconomic behaviors.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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Authors and funding
34 authors at 17 institutions in 9 countries.
Nathalie E HolzDonders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, the Netherlands. nathalie.holz@zi-mannheim.de.ORCID http://orcid.org/0000-0002-6225-9267
Mariam ZabihiDonders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, the Netherlands.ORCID http://orcid.org/0000-0002-7083-2318
Seyed Mostafa KiaDonders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, the Netherlands.ORCID http://orcid.org/0000-0002-7128-814X
Maximillian MonningerDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Pascal-M AggensteinerDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Sebastian SiehlInstitute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, Germany.ORCID http://orcid.org/0000-0002-8933-7552
Dorothea L FlorisDonders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, the Netherlands.
Arun L W BokdeDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0003-0114-4914
Sylvane DesrivièresSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-9120-7060
Herta FlorInstitute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0003-4809-5398
Antoine GrigisNeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.
Hugh GaravanDepartments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA.
Penny GowlandSir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK.ORCID http://orcid.org/0000-0002-4900-4817
Andreas HeinzDepartment of Psychiatry and Psychotherapy CCM, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.ORCID http://orcid.org/0000-0001-5405-9065
Rüdiger BrühlPhysikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0003-0111-5996
Jean-Luc MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM U1299 'Developmental Trajectories & Psychiatry'; Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, France.
Marie-Laure Paillère MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM U1299 'Developmental Trajectories & Psychiatry'; Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0002-0452-2450
Dimitri Papadopoulos OrfanosNeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0002-1242-8990
Tomáš PausDepartments of Psychiatry and Neuroscience and Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, Quebec, Canada.
Luise PoustkaDepartment of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine, Heidelberg University, Heidelberg, Germany.
Juliane H FröhnerDepartment of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany.ORCID http://orcid.org/0000-0002-8493-6396
Michael N SmolkaDepartment of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany.ORCID http://orcid.org/0000-0001-5398-5569
Nilakshi VaidyaPONS-Centre, Department of Psychiatry and Clinical Neuroscience, CCM, Charite University Medicine, Berlin, Germany.
Henrik WalterDepartment of Psychiatry and Psychotherapy CCM, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.ORCID http://orcid.org/0000-0002-9403-6121
Robert WhelanSchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0002-2790-7281
Gunter SchumannPONS-Centre, Department of Psychiatry and Clinical Neuroscience, CCM, Charite University Medicine, Berlin, Germany.ORCID http://orcid.org/0000-0002-7740-6469
Andreas Meyer-LindenbergDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0001-5619-1123
Daniel BrandeisDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Jan K BuitelaarDonders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, the Netherlands.ORCID http://orcid.org/0000-0001-8288-7757
Frauke NeesInstitute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, Germany.
Christian BeckmannDonders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, the Netherlands.
IMAGEN Consortium
Tobias Banaschewski *Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Andre F Marquand *Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, the Netherlands. a.marquand@donders.ru.nl.
Radboud University Nijmegen · NLHeidelberg University · DECentre National de la Recherche Scientifique · FRTechnische Universität Dresden · DEHumboldt-Universität zu Berlin · DECommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRTrinity College Dublin · IECharité - Universitätsmedizin Berlin · DEChristian-Albrechts-Universität zu Kiel · DEFudan University · CNKing's College London · GBPhysikalisch-Technische Bundesanstalt · DEUniversity of Mannheim · DEUniversity of Nottingham · GBUniversity of Toronto · CAUniversity of Vermont · USUniversity of Zurich · CH
Funding
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MA decentralized macro and micro gene-by-environment interaction analysis of substance use behavior and its brain biomarkers R01DA049238 · NIDA · GEORGIA STATE UNIVERSITY · PI CALHOUN, VINCE D, LIU, JINGYU · 2019 to 2023
$2.9MAxon, Testosterone and Mental Health during AdolescenceR01MH085772 · NIMH · BAYCREST CENTRE FOR GERIATRIC CARE · PI PAUS, TOMAS · 2010 to 2014
$1.5MENIGMA World Aging CenterR56AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2018
$683kMedical Research Council MR/R00465X/1Medical Research Council MR/S020306/1Medical Research Council MR/W002418/1MRF_ MRF-058-0004-RG-DESRIMRF_ MRF-058-0009-RG-DESR-C0759NIA NIH HHS R56 AG058854NIBIB NIH HHS U54 EB020403NIDA NIH HHS R01 DA049238NIMH NIH HHS R01 MH085772Wellcome Trust
Abstract
Environmental adversities constitute potent risk factors for psychiatric disorders. Evidence suggests the brain adapts to adversity, possibly in an adversity-type and region-specific manner. However, the long-term effects of adversity on brain structure and the association of individual neurobiological heterogeneity with behavior have yet to be elucidated. Here we estimated normative models of structural brain development based on a lifespan adversity profile in a longitudinal at-risk cohort aged 25 years (n = 169). This revealed widespread morphometric changes in the brain, with partially adversity-specific features. This pattern was replicated at the age of 33 years (n = 114) and in an independent sample at 22 years (n = 115). At the individual level, greater volume contractions relative to the model were predictive of future anxiety. We show a stable neurobiological signature of adversity that persists into adulthood and emphasize the importance of considering individual-level rather than group-level predictions to explain emerging psychopathology.
Indexed as
LongevityMental DisordersAdultAnxietyBrainHumansNeurobiology
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