Evidence map›Paper›PMID 37604649›Full record

ArticleOpen heart2023

Long-term outcomes among stable post-acute myocardial infarction patients living in rural versus urban areas: insights from the prospective, observational TIGRIS registry.

Jose Carlos Nicolau, Ruth Owen, Remo H M Furtado, Shaun G Goodman, Christopher B Granger, Mauricio G Cohen, Dirk Westermann, Satoshi Yasuda, Tabassome Simon, Katarina Hedman and 3 more

Registry-linked trialAbstract read
In one paragraph

Article in Open heart, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01866904 (TIGRIS), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01866904 terminatednot on this map

TIGRIS: Long-Term rIsk, Clinical manaGement and Healthcare Resource Utilization of Stable Coronary Artery dISease in Post Myocardial Infarction Patients

TypeobservationalSponsorAstraZenecaRan2013 to 2017Enrolled9,284ConditionsStable Coronary Artery Disease (CAD), Myocardial Infarction
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jose Carlos NicolauInstituto do Coracao (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil corjnicolau@incor.usp.br.ORCID 0000-0002-9680-3689
Ruth OwenLondon School of Hygiene and Tropical Medicine, London, UK.
Remo H M FurtadoInstituto do Coracao (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Shaun G GoodmanTerrence Donnelly Heart Centre, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Christopher B GrangerDuke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA.
Mauricio G CohenCleveland Clinic Florida, Heart & Vascular Center, Cleveland, Ohio, USA.ORCID 0000-0003-2038-6070
Dirk WestermannDepartment of General and Interventional Cardiology, University Heart Center Hamburg Eppendorf, Hamburg, Germany.ORCID 0000-0002-7542-1956
Satoshi YasudaDepartment of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.
Tabassome SimonDepartment of Clinical Pharmacology and Research Platform of East of Paris, Assistance Publique-Hôpitaux de Paris, Paris, France.
Katarina HedmanBioPharmaceuticals R&D, CVRM Biometrics, AstraZeneca, Gothenburg, Sweden.
Phillip R HuntAstraZeneca, Gaithersburg, Maryland, USA.
David B BriegerCardiology Department, Concord Hospital, Sydney, New South Wales, Australia.ORCID 0000-0001-6115-0326
Stuart J PocockLondon School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0003-2212-4007

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInsights on the differences in clinical outcomes, quality of life (QoL) and health resource utilisation (HRU) with different levels of care available to post-acute myocardial infarction (AMI) populations in rural and urban settings are limited.

methodsThe long-Term rIsk, clinical manaGement, and healthcare Resource utilisation of stable coronary artery dISease (TIGRIS), a prospective, observational registry, enrolled 8452 patients aged ≥50 years 1-3 years post-AMI from June 2013 to November 2014 from 24 countries in Asia Pacific/Australia, Europe, North America and South America. Differences in QoL (measured using the EuroQol Research Foundation instrument) and HRU between patients in rural and urban settings were evaluated in this post hoc analysis. The incidence of clinical endpoints (cardiovascular (CV) death, AMI, unstable angina with urgent revascularisation and stroke; bleeding; and all-cause mortality) was analysed. Data were collected at baseline and every 6 months for 24 months.

resultsThere were fewer hospitalisations and visits to general practitioners (GPs) and cardiologists in the rural versus urban populations (adjusted event rate ratio (ERR)=0.90 (95% CI, 0.82 to 1.00, p=0.04); ERR=0.84 (95% CI, 0.78 to 0.92, p<0.001); ERR=0.86 (95% CI, 0.81 to 0.92, p<0.001), respectively). No statistically significant differences were observed between rural and urban populations in all-cause death, AMI, unstable angina with urgent revascularisation, CV death, stroke, major bleeding events and health-related QoL. The adjusted incidence rate ratio was 0.92 (95% CI, 0.74 to 1.15) for the composite of CV death, AMI and stroke.

conclusionsLiving in rural areas was associated with fewer GP/cardiologist visits and hospitalisations; no significant differences in clinical outcomes and QoL were observed. TRIAL REGISTRATION NUMBER: NCT01866904.

Indexed as

Myocardial InfarctionStrokeAngina, UnstableHumansProspective StudiesQuality of LifeRegistriescoronary artery diseasemyocardial infarctionquality of health care

Identifiers

PMID37604649
PMCPMC10445369

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.