ArticleAnnals of medicine2023
High systemic inflammation response index level is associated with an increased risk of lower extremity deep venous thrombosis: a large retrospective study.
Article in Annals of medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Pooled it
- Article
- The Effectiveness of Systemic Immune-Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) and Model for End-Stage Liver Disease (MELD) Score in Predicting Prognosis in Portal Vein Thrombosis, a Pilot Study.Diagnostics (Basel, Switzerland) · 2026Article
- Development and validation of a prediction model for venous thromboembolic events following hematoma evacuation in patients with spontaneous intracerebral hemorrhage.Neurosurgical review · 2025Article
- A prospective cohort study on the joint associations of abdominal aortic calcification and systemic inflammation response index with mortality risk.Scientific reports · 2025Article
- Two sides of the coin: coagulation and inflammation in deep vein thrombosis - a prospective study on D-dimer and SIRI.Frontiers in medicine · 2025Article
- Association between stroke and systemic inflammation response index (SIRI): a National Health and Nutrition Examination Survey (NHANES) Study 2015-2020.BMJ neurology open · 2025Article
- Evidence for causal effects of neuropsychiatric conditions on risk of venous thromboembolism: A univariable and multivariable Mendelian randomization study.Journal of vascular surgery. Venous and lymphatic disorders · 2024Review
- Should we consider Systemic Inflammatory Response Index (SIRI) as a new diagnostic marker for rectal cancer?Discover oncology · 2024Article
- Association of systemic inflammation response index with mortality risk in older patients with hip fracture: a 10-year retrospective cohort study.Frontiers in medicine · 2024Article
- The systemic inflammation response index as a significant predictor of short-term adverse outcomes in acute decompensated heart failure patients: a cohort study from Southern China.Frontiers in endocrinology · 2024Article
- Prognostic Nutritional Index as a Potential Biomarker for the Risk of Lower Extremity Deep Venous Thrombosis: A Large Retrospective Study.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association between inflammation and venous thromboembolism (VTE) has attracted increasing research interest. Recently, the systemic inflammation response index (SIRI) has been proposed as a novel inflammatory biomarker, but its potential association with lower extremity deep venous thrombosis (LEDVT) has not been investigated. Thus, this study aimed to explore the association between SIRI and LEDVT risk in a large sample over a 10-year period (2012-2022).
methodsAll hospitalized patients who underwent lower extremity compression ultrasonography (CUS) examinations were consecutively identified from our hospital information system database. Multivariate logistic regression analysis was used to investigate the association between SIRI and LEDVT risk. Sensitivity, restricted cubic spline and subgroup analyses were also performed.
resultsIn total, 12643 patients were included, and 1346 (10.6%) LEDVT events occurred. After full adjustment, a higher SIRI level was significantly associated with an increased risk of LEDVT (odds ratio [OR] = 1.098, 95% confidence interval [
conclusionA High SIRI is significantly associated with an increased risk of LEDVT in hospitalized patients. Given that the SIRI is a readily available biomarker in clinical settings, its potential clinical use deserves further exploration.
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