Evidence map›Paper›PMID 37603775›Full record

ArticleFrontiers in molecular neuroscience2023

A new Hoxb8FlpO mouse line for intersectional approaches to dissect developmentally defined adult sensorimotor circuits.

Manon Bohic, Aman Upadhyay, Jaclyn T Eisdorfer, Jessica Keating, Rhiana C Simon, Brandy A Briones, Chloe Azadegan, Hannah D Nacht, Olisemeka Oputa, Alana M Martinez and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Keratinocyte-TRPV1 sensory neuron interactions in a genetically controllable mouse model of chronic neuropathic itch.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Manon BohicCell Biology and Neuroscience Department, Rutgers University, The State University of New Jersey, Piscataway, NJ, United States.
Aman UpadhyayCell Biology and Neuroscience Department, Rutgers University, The State University of New Jersey, Piscataway, NJ, United States.
Jaclyn T EisdorferCell Biology and Neuroscience Department, Rutgers University, The State University of New Jersey, Piscataway, NJ, United States.
Jessica KeatingCell Biology and Neuroscience Department, Rutgers University, The State University of New Jersey, Piscataway, NJ, United States.
Rhiana C SimonCenter for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Washington, Seattle, WA, United States.
Brandy A BrionesCenter for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Washington, Seattle, WA, United States.
Chloe AzadeganCell Biology and Neuroscience Department, Rutgers University, The State University of New Jersey, Piscataway, NJ, United States.
Hannah D NachtCell Biology and Neuroscience Department, Rutgers University, The State University of New Jersey, Piscataway, NJ, United States.
Olisemeka OputaCell Biology and Neuroscience Department, Rutgers University, The State University of New Jersey, Piscataway, NJ, United States.
Alana M MartinezCell Biology and Neuroscience Department, Rutgers University, The State University of New Jersey, Piscataway, NJ, United States.
Bridget N BethellInternational Collaboration on Repair Discoveries and Department of Zoology, The University of British Columbia, Vancouver, BC, Canada.
Mark A GradwellCell Biology and Neuroscience Department, Rutgers University, The State University of New Jersey, Piscataway, NJ, United States.
Peter RomanienkoGenome Editing Shared Resource, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, United States.
Matt S RamerInternational Collaboration on Repair Discoveries and Department of Zoology, The University of British Columbia, Vancouver, BC, Canada.
Garret D StuberCenter for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Washington, Seattle, WA, United States.
Victoria E AbrairaCell Biology and Neuroscience Department, Rutgers University, The State University of New Jersey, Piscataway, NJ, United States.
Rutgers, The State University of New Jersey · USUniversity of Washington · USInternational Collaboration On Repair Discoveries · CAOregon Health & Science University · USRutgers Cancer Institute · USUniversity of British Columbia · CA

Funding

X-RAY STRUCTURE OF RIFM PROTEIN FROM THE BIOSYNTHESIS PATHWAY OF THE ANSAMYCIN AP41RR012408 · NCRR · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI MARIUZZA, ROY A · 1998 to 2011
$32.2M
University of Washington Center of Excellence in Opioid Addiction ResearchP30DA048736 · NIDA · UNIVERSITY OF WASHINGTON · PI Charles Chavkin · 2019 to 2026
$13.0M
Rutgers Biotechnology Training ProgramT32GM135141 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI ANN M. STOCK, Martin L Yarmush · 2020 to 2026
$3.5M
Touching on locomotion: Olise Oputa Diversity Supplement_Nov 15R01NS119268 · NINDS · RUTGERS, THE STATE UNIV OF N.J. · PI ABRAIRA, VICTORIA EUGENIA GUADALUPE · 2020 to 2024
$2.5M
Refining Oxytocin Therapy for Pain: Context is KeyR01NS124799 · NINDS · RUTGERS, THE STATE UNIV OF N.J. · PI Victoria Eugenia Guadalupe Abraira · 2023 to 2026
$2.0M
Training in Translating Neuroscience to TherapiesT32NS115700 · NINDS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI MOURADIAN, M. MARAL · 2021 to 2025
$1.4M
A new mechanistic and technological framework for uncovering the spinal cord neural systems important for functional recovery after injuryK01NS116224 · NINDS · RUTGERS, THE STATE UNIV OF N.J. · PI ABRAIRA, VICTORIA EUGENIA GUADALUPE · 2020 to 2024
$1.2M
NCRR NIH HHS P41 RR012408NIDA NIH HHS P30 DA048736NIGMS NIH HHS T32 GM135141NINDS NIH HHS K01 NS116224NINDS NIH HHS R01 NS119268NINDS NIH HHS R01 NS124799NINDS NIH HHS T32 NS115700
6 · The paper itself

Abstract

Improvements in the speed and cost of expression profiling of neuronal tissues offer an unprecedented opportunity to define ever finer subgroups of neurons for functional studies. In the spinal cord, single cell RNA sequencing studies support decades of work on spinal cord lineage studies, offering a unique opportunity to probe adult function based on developmental lineage. While Cre/Flp recombinase intersectional strategies remain a powerful tool to manipulate spinal neurons, the field lacks genetic tools and strategies to restrict manipulations to the adult mouse spinal cord at the speed at which new tools develop. This study establishes a new workflow for intersectional mouse-viral strategies to dissect adult spinal function based on developmental lineages in a modular fashion. To restrict manipulations to the spinal cord, we generate a brain-sparing

Indexed as

dorsal root ganglion (DRG)genetic toolsneurosciencesensorimotor systemspinal cord

Identifiers

PMID37603775
PMCPMC10437123
OpenAlexW4385460202

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.