Evidence map›Paper›PMID 37603749›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Gap junction-transported cAMP from the niche controls stem cell progeny differentiation.

Renjun Tu, Xiaohan Alex Tang, Rui Xu, Zhaohua Ping, Zulin Yu, Ting Xie

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Harnessing the Power ofCold Spring Harbor perspectives in biology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Controllable gap junctions by vitamin BProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Gap junction-transported cAMP from the niche controls stem cell progeny differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Renjun Tu *Division of Life Science, The Hong Kong University of Science and Technology, Kowloon, Hong Kong Special Administrative Region (SAR), China.ORCID 0000-0003-2764-2575
Xiaohan Alex Tang *Division of Life Science, The Hong Kong University of Science and Technology, Kowloon, Hong Kong Special Administrative Region (SAR), China.ORCID 0009-0002-8399-3679
Rui Xu *Division of Life Science, The Hong Kong University of Science and Technology, Kowloon, Hong Kong Special Administrative Region (SAR), China.ORCID 0009-0004-0085-5049
Zhaohua PingStowers Institute for Medical Research, Kansas City, MO 64110.ORCID 0000-0002-4671-7862
Zulin YuStowers Institute for Medical Research, Kansas City, MO 64110.
Ting XieDivision of Life Science, The Hong Kong University of Science and Technology, Kowloon, Hong Kong Special Administrative Region (SAR), China.ORCID 0000-0003-4769-986X
Hong Kong University of Science and Technology · HKStowers Institute for Medical Research · US

Funding

Drosophila Transgenic RNAi Resource ProjectR01GM084947 · NIGMS · HARVARD MEDICAL SCHOOL · PI PERRIMON, NORBERT · 2008 to 2019
$9.8M
Investigation of Niche Control of Germline Stem Cell Lineage DifferentiationR01HD097664 · NICHD · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI XIE, TING · 2019 to 2020
$685k
NICHD NIH HHS R01 HD097664NIGMS NIH HHS R01 GM084947
6 · The paper itself

Abstract

The niche has been shown to control stem cell self-renewal in different tissue types and organisms. Recently, a separate niche has been proposed to control stem cell progeny differentiation, called the differentiation niche. However, it remains poorly understood whether and how the differentiation niche directly signals to stem cell progeny to control their differentiation. In the

Indexed as

Adult Stem CellsAnimalsBiological TransportCell DifferentiationCell Self RenewalDrosophilaFemaleGap JunctionscAMPdifferentiationgap junctionnichestem cell

Identifiers

PMID37603749
PMCPMC10468610
OpenAlexW4386022028

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.