ArticleBMJ mental health2023
Development and validation of a dementia risk score in the UK Biobank and Whitehall II cohorts.
Article in BMJ mental health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Discriminative performance of externally validated dementia risk prediction models: a systematic review and meta-analysis.BMC medicine · 2026Pooled it
- A critical review and classification of dementia risk assessment tools to inform dementia risk reduction.The journal of prevention of Alzheimer's disease · 2025Pooled it
- Predicting cognitive decline: Comparative analysis of ANU-ADRI, CAIDE, CogDrisk, LIBRA, LIBRA2, UKBDRS and Lancet based dementia risk scores in the HUNT study.The journal of prevention of Alzheimer's disease · 2026Article
- Development and validation of the LateDem-Risk score to predict dementia incidence in the InveCe.Ab and Trelong Italian cohorts.Scientific reports · 2026Article
- Hearing screening for healthy aging: the U.K. should take a targeted approach.The Gerontologist · 2026Article
- Liver Fibrosis and the Risks of Impaired Cognition and Dementia: Mechanisms, Evidence, and Clinical Implications.Medical sciences (Basel, Switzerland) · 2026Review
- Cardiovascular Risk as a Moderator of the Relationship Between Plasma Alzheimer Disease Biomarkers and Cognitive Status.Journal of the American Heart Association · 2026Article
- A brief checklist of modifiable dementia risk factors (RF12): associations with cognitive and affective measures in an Italian cohort.Frontiers in aging neuroscience · 2026Article
- External validation of dementia risk prediction models in the EPIC-Norfolk cohort: a UK-based cohort study.NPJ dementia · 2026Article
- Predicting Dementia Risk: Progress, Pitfalls, and Priorities.International journal of public health · 2026Article
- Association between neutrophil to lymphocyte ratio and Alzheimer's disease in large biobank cohorts.Journal of Alzheimer's disease : JAD · 2025Article
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- Dementia risk prediction: A comparative analysis of the ANU-ADRI, CAIDE, CogDrisk, LIBRA, and LIBRA2 indices in the HUNT study.The journal of prevention of Alzheimer's disease · 2025Article
- Association of Android and Gynoid Fatness With Incident Dementia and Brain Structure.Journal of cachexia, sarcopenia and muscle · 2025Article
- Development of a midlife-specific CogDrisk algorithm (CogDrisk-ML) to enable validated implementation of dementia risk assessment from midlife to late life.Age and ageing · 2025Article
- Article
- Article
- Investigating the relevance of nucleotide metabolism in the prognosis of glioblastoma through bioinformatics models.Scientific reports · 2025Article
- Latent profiles of modifiable dementia risk factors in later midlife: relationships with incident dementia, cognition, and neuroimaging outcomes.Molecular psychiatry · 2025Article
- Suggestions for the decision making in subjective cognitive complaints.Aging clinical and experimental research · 2025Review
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Authors and funding
12 authors.
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Abstract
backgroundCurrent dementia risk scores have had limited success in consistently identifying at-risk individuals across different ages and geographical locations.
objectiveWe aimed to develop and validate a novel dementia risk score for a midlife UK population, using two cohorts: the UK Biobank, and UK Whitehall II study.
methodsWe divided the UK Biobank cohort into a training (n=176 611, 80%) and test sample (n=44 151, 20%) and used the Whitehall II cohort (n=2934) for external validation. We used the Cox LASSO regression to select the strongest predictors of incident dementia from 28 candidate predictors and then developed the risk score using competing risk regression.
findingsOur risk score, termed the UK Biobank Dementia Risk Score (UKBDRS), consisted of age, education, parental history of dementia, material deprivation, a history of diabetes, stroke, depression, hypertension, high cholesterol, household occupancy, and sex. The score had a strong discrimination accuracy in the UK Biobank test sample (area under the curve (AUC) 0.8, 95% CI 0.78 to 0.82) and in the Whitehall cohort (AUC 0.77, 95% CI 0.72 to 0.81). The UKBDRS also significantly outperformed three other widely used dementia risk scores originally developed in cohorts in Australia (the Australian National University Alzheimer's Disease Risk Index), Finland (the Cardiovascular Risk Factors, Ageing, and Dementia score), and the UK (Dementia Risk Score). CLINICAL IMPLICATIONS: Our risk score represents an easy-to-use tool to identify individuals at risk for dementia in the UK. Further research is required to determine the validity of this score in other populations.
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