ArticleThe Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology2023
Clinical Outcomes of Older Patients with Non-Variceal Upper Gastrointestinal Bleeding Taking Anti-Thrombotic or Non-Steroidal Anti-Inflammatory Agents.
Article in The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 11 citations in OpenAlex.
- Impact of antithrombotic therapy on management and prognosis of patients hospitalized for upper gastrointestinal bleeding: a multicenter retrospective cohort study.Internal and emergency medicine · 2026Article
- Optimal endoscopy timing in elderly patients presenting with acute non-variceal upper gastrointestinal bleeding.BMC gastroenterology · 2024Article
- Regarding re-bleeding and all-cause mortality risk in non-variceal upper gastrointestinal bleeding: focusing on patients receiving oral anticoagulant therapy.Annals of medicine · 2024Article
- Rupture of Hepatic Artery Aneurysm as a Cause of Severe Upper Gastrointestinal Bleeding and Cholangitis in a Liver Transplanted Patient.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024Article
- Optimal Timing of Endoscopy in Patients Taking Anticoagulants with Upper Gastrointestinal Bleeding.Digestive diseases and sciences · 2024Article
- Response to "Optimal Timing of Endoscopy in Patients Taking Anticoagulants with Upper Gastrointestinal Bleeding".Digestive diseases and sciences · 2024Article
- Unusual Cause of Gastrointestinal Bleeding in an Elderly Adult: Gastric Kissing Ulcers.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024Article
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Authors and funding
3 authors at 3 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsNon-variceal upper gastrointestinal bleeding is a well-established complication of non-steroidal anti-inflammatory drugs and anti-thrombotics. Both medication groups are frequently used by older populations and increase the incidence of non-var- iceal upper gastrointestinal bleeding; however, their impact on etiology and outcomes of non-variceal upper gastrointestinal bleeding has not been well defined. We aimed to compare the etiology and outcomes of non-variceal upper gastrointestinal bleeding in older patients who use anti-thrombotics and non-steroidal anti-inflammatory drugs or do not use either of them. MATERIALS AND
methodsThis is a single-center prospective study of patients older than 65 years with non-variceal upper gastrointesti- nal bleeding. Endoscopic findings, laboratory values, blood transfusion, endoscopic treatment, re-bleeding, and 30-day mortality rates were recorded.
resultsA total of 257 patients (median age 77.7 ± 8.2, 59% male) were included. Re-bleeding occurred in 25 (10%) and the 30-day mortality rate was 40 (16%). There was no statistically significant difference between patients using anti-thrombotics, non-steroidal anti-inflammatory drugs or non-users for blood transfusion (P = .46), endoscopic hemostasis (P = .39), re-bleeding (P = .09), and 30-day mortality (P = .45). Peptic ulcer was the most common etiology in all groups (124, 48%). Although the incidence of peptic ulcer was similar between drug users and anti-thrombotic users (P = .75), the incidence of peptic ulcer was significantly higher in patients using non-steroidal anti-inflammatory drugs than in patients who did not use drugs (P = .05). When the patients were analyzed as using anti- thrombotic drugs or non-steroidal anti-inflammatory drugs or neither, no statistically significant difference was found between ulcer location, ulcer number, and ulcer size.
conclusionNon-variceal upper gastrointestinal bleeding increasingly occurs in older populations with several comorbidities; non- steroidal anti-inflammatory drugs or anti-thrombotics do not seem to change the clinical outcomes among older patients with non- variceal upper gastrointestinal bleeding.
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