Evidence map›Paper›PMID 37603214›Full record

ArticleNeurochemical research2024

Modulation of Multidrug Resistance Protein 1-mediated Transport Processes by the Antiviral Drug Ritonavir in Cultured Primary Astrocytes.

Christian Arend, Isabell L Grothaus, Mario Waespy, Lucio Colombi Ciacchi, Ralf Dringen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurochemical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Christian Arend *Centre for Biomolecular Interactions Bremen, Faculty 2 (Biology/Chemistry), University of Bremen, P.O. Box 330440, 28359, Bremen, Germany. christian.arend@uni-bremen.de.ORCID http://orcid.org/0000-0001-8690-6257
Isabell L Grothaus *Centre for Environmental Research and Sustainable Technology, University of Bremen, Bremen, Germany.ORCID http://orcid.org/0000-0002-0441-3860
Mario WaespyCentre for Biomolecular Interactions Bremen, Faculty 2 (Biology/Chemistry), University of Bremen, P.O. Box 330440, 28359, Bremen, Germany.ORCID http://orcid.org/0000-0003-0039-5770
Lucio Colombi CiacchiCentre for Environmental Research and Sustainable Technology, University of Bremen, Bremen, Germany.ORCID http://orcid.org/0000-0003-1444-9733
Ralf DringenCentre for Biomolecular Interactions Bremen, Faculty 2 (Biology/Chemistry), University of Bremen, P.O. Box 330440, 28359, Bremen, Germany.ORCID http://orcid.org/0000-0001-7869-1305
University of Bremen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Multidrug Resistance Protein 1 (Mrp1) is an ATP-dependent efflux transporter and a major facilitator of drug resistance in mammalian cells during cancer and HIV therapy. In brain, Mrp1-mediated GSH export from astrocytes is the first step in the supply of GSH precursors to neurons. To reveal potential mechanisms underlying the drug-induced modulation of Mrp1-mediated transport processes, we investigated the effects of the antiviral drug ritonavir on cultured rat primary astrocytes. Ritonavir strongly stimulated the Mrp1-mediated export of glutathione (GSH) by decreasing the K

Indexed as

AstrocytesATP Binding Cassette Transporter, Subfamily B, Member 1AnimalsAntiviral AgentsATP-Binding Cassette, Sub-Family C ProteinsBiological TransportCells, CulturedGlutathioneGlutathione DisulfideMammalsRatsRitonavirAntiviral AgentsATP-Binding Cassette, Sub-Family C ProteinsATP Binding Cassette Transporter, Subfamily B, Member 1GlutathioneGlutathione DisulfideRitonavirAstrocyteGlutathioneMolecular Dynamics SimulationMrp1Ritonavir¸ Transport

Identifiers

PMID37603214
PMCPMC10776481
OpenAlexW4386019471

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.