Evidence map›Paper›PMID 37603178›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2023

Methods to Study TLRs in Transplantation.

Montserrat Kwan, Martin Sepulveda, Maria-Luisa Alegre

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Montserrat KwanDepartment of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA.
Martin SepulvedaDepartment of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA.
Maria-Luisa AlegreDepartment of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA. malegre@bsd.uchicago.edu.
University of Chicago · US

Funding

Impact of Microbiota on Alloimmune Responses in TransplantationR01AI115716 · NIAID · UNIVERSITY OF CHICAGO · PI ALEGRE, MARIA-LUISA · 2015 to 2024
$4.3M
NIAID NIH HHS R01 AI115716
6 · The paper itself

Abstract

Toll-like receptors (TLRs) are key regulators of immune responses, including alloimmune responses. In this chapter, we present protocols to study whether and/or how TLRs can contribute to solid-organ transplant rejection. We describe methods to reduce heterogeneity in microbiome variations between animals before beginning experiments to limit confounding factors, protocols using TLR agonists to prevent anti-CD154/donor splenocyte transfer-mediated tolerance, and recipes to heat-kill microbes or use hosts genetically deficient in TLR-dependent pathways to distinguish between TLR-dependent and live bacteria-dependent effects.

Indexed as

Organ TransplantationAdjuvants, ImmunologicAnimalsCD40 LigandHumansTissue DonorsToll-Like ReceptorsAdjuvants, ImmunologicCD40 LigandToll-Like ReceptorsCostimulation blockadeHeart transplantationMicrobiomeMicrobiotaSkin transplantationSolid-organ transplantationToll-like receptors

Identifiers

PMID37603178
OpenAlexW4386019575

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.