Evidence map›Paper›PMID 37603170›Full record

Trial reportClinical oral investigations2023

Comparative evaluation of four treatments for postorthodontic white spot lesions: a randomized controlled trial.

Qiqiu Wang, Yang Zhou, Tianqiang Cui, Jianbo Li, E C M Lo, Gaofeng Hao, Qinghui Zhi

Abstract readRandomized Controlled TrialComparative Study
PubMed Publisher
In one paragraph

Trial report in Clinical oral investigations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Qiqiu WangHospital of Stomatology, Sun Yat-Sen University, No. 56, Lingyuan Xi Road, Guangzhou, 510055, China.
Yang ZhouHospital of Stomatology, Sun Yat-Sen University, No. 56, Lingyuan Xi Road, Guangzhou, 510055, China.
Tianqiang CuiFoshan Stomatological Hospital & School of Medicine, Foshan University, Foshan, China.
Jianbo LiSchool of Stomatology, Stomatological Hospital, Southern Medical University, Guangzhou, China.
E C M LoFaculty of Dentistry, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Gaofeng HaoOral Disease Prevention Center of Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, China. haogaofeng789@163.com.
Qinghui ZhiHospital of Stomatology, Sun Yat-Sen University, No. 56, Lingyuan Xi Road, Guangzhou, 510055, China. zhiqingh@mail.sysu.edu.cn.
Sun Yat-sen University · CNFoshan University · CNHospital of Stomatology, Sun Yat-sen UniversityShenzhen Maternity and Child Healthcare Hospital · CNSouthern Medical University · CNUniversity of Hong Kong · HK

Funding

First Class Hospital Clinical Trial Project in Guangdong Province 103007-6-2019-GSP-D
6 · The paper itself

Abstract

objectivesTo evaluate the treatment efficacy of fluoride toothpaste alone and those of adjunctive use of resin infiltration, sodium fluoride varnish, and casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on white spot lesions (WSLs). MATERIALS AND

methodsSeventy-nine patients (356 teeth) with WSLs after orthodontic treatment were randomly allocated into four groups. The WSLs of the participants received resin infiltration only at baseline, and the other groups received fluoride varnish, CPP-ACP mousse, and placebo treatment every 6 months, respectively. A toothpaste containing 1400 ppm fluoride and toothbrushes were distributed to all participants, and oral hygiene instructions were provided. Photos of the teeth with WSL were taken to compare the change between groups which was measured by ImageJ software.

resultsTwelve months later, different degrees of reduction in the area of WSLs were observed in all groups. The percentage of lesion area reduction in WSLs in the resin infiltration group was 46.6%, which was significantly higher than that in fluoride varnish group (26.6%), CPP-ACP group (28.6%), and control group (29.8%), and the differences were statistically significant (p < 0.001).

conclusionsThis study shows that after 1-year follow-up, the use of fluoride toothpaste, with or without the use of fluoride varnish or CPP-ACP, can reduce the area of WSLs. While resin infiltration can immediately improve dental aesthetics and continuously improved in 12 months, resin infiltration group showed much better results than other groups.

trial registrationClinical Trials Registration Number: ChiCTR2000032516. CLINICAL SIGNIFICANCE: The use of fluoride toothpaste, with or without adjunctive use of fluoride varnish and CPP-ACP, can reduce the area of WSLs, while resin infiltration treatment has additional effect and can immediately improve dental aesthetics.

Indexed as

Cariostatic AgentsCaseinsDental CariesFluorides, TopicalSodium FluorideToothpastesAdolescentAdultFemaleHumansMaleTreatment OutcomeCariostatic Agentscasein phosphopeptide-amorphous calcium phosphate nanocomplexCaseinsFluorides, TopicalSodium FluorideToothpastesCasein phosphopeptide-amorphous calcium phosphateFluoride toothpasteFluoride varnishRemineralizationResin infiltrationWhite spot lesions

Identifiers

PMID37603170
OpenAlexW4386019931

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.