ArticleRadiologie (Heidelberg, Germany)2023
Age-related changes in the healthy adult visual pathway: evidence from diffusion tensor imaging with fixel-based analysis.
Article in Radiologie (Heidelberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 2 citations in OpenAlex.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeFixel-based analysis (FBA) is a new method that overcomes the technical limitations of diffusion tensor imaging (DTI) by enabling the characterization of multiple fiber populations within a voxel, and provides biologically meaningful indicators. This study aimed to explore age-related changes in the visual pathway in healthy adults and to observe differences in imaging quality between data collected using different b‑values.
methodsIn this prospective cross-sectional study, brain DTI scans which were collected with more than six uniformly distributed gradient directions and higher b‑values (up to 2000 s/mm
resultsPearson's correlation analysis showed that DTI parameters of white matter (optic nerve, optic chiasma, optic tract, and optic radiation) in the optic pathway were correlated with age. FA values were negatively correlated with age, while MD/AD/RD showed a positive correlation (P < 0.05). FBA showed that the index including FD/FC/FDC tended to decline with age (P < 0.05). Linear regression analysis showed a linear relationship between DTI metrics of the dataset collected by b‑values of 1000 and 2000 s/mm
conclusionFBA provides a useful method to assess age-related changes in the visual pathway, which is sensitive to diffusion. In addition, the b‑value influences DTI parameters and signal-to-noise ratio of the image.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.