Evidence map›Paper›PMID 37602830›Full record

SynthesisCancer medicine2023

A systematic review of the effectiveness of patient-initiated follow-up after cancer.

Janine Dretzke, Talhah Chaudri, Rishab Balaji, Hisham Mehanna, Paul Nankivell, David J Moore, PETNECK2 Research Team

Registry-linked trialAbstract readSystematic Review
In one paragraph

Synthesis in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07572370 (Evaluating the De-Escalation of Surveillance for Patients Who Have Undergone Curative Treatment for Primary Breast Cancer - A Prospective, Randomised Controlled Trial), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07572370 recruitingnot on this mapstarted 2025, after this paper: background citation

Evaluating the De-Escalation of Surveillance for Patients Who Have Undergone Curative Treatment for Primary Breast Cancer - A Prospective, Randomised Controlled Trial

TypeobservationalSponsorRoyal College of Surgeons, IrelandRan2025 to 2028Enrolled560ConditionsBreast CancerArmsDeescalation of surveillance
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Follow-up of women after gynecological cancer treatment.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025
    Article
  7. Article
  8. In pursuit of a functional cure for follicular lymphoma.Hematology. American Society of Hematology. Education Program · 2024
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Janine DretzkeInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.ORCID 0000-0002-2591-6918
Talhah ChaudriBirmingham Medical School, University of Birmingham, Birmingham, UK.
Rishab BalajiBirmingham Medical School, University of Birmingham, Birmingham, UK.
Hisham MehannaInstitute for Head and Neck Studies and Education, University of Birmingham, Birmingham, UK.
Paul NankivellInstitute for Head and Neck Studies and Education, University of Birmingham, Birmingham, UK.ORCID 0000-0003-4664-6117
David J MooreInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.
PETNECK2 Research Team

Funding

National Institute for Health and Care Research (NIHR) NIHR200861
6 · The paper itself

Abstract

backgroundThe traditional cancer follow-up (FU) model for cancer survivors is by scheduled clinic appointments; however, this is not tailored to patient needs and is becoming unsustainable. Patient-initiated follow-up (PIFU) may be a more effective and flexible alternative. This systematic review aims to analyse all existing evidence from randomised controlled trials (RCTs) on the effectiveness of PIFU compared with other FU models that include routinely scheduled appointments in adults who have been treated with curative intent for any type of cancer.

methodsStandard systematic review methodology aimed at limiting bias was used for study identification, selection and data extraction. MEDLINE, Embase, CINAHL, the Cochrane Database of Systematic Reviews and Epistemonikos were searched for systematic reviews to March 2022, and Cochrane CENTRAL was searched for RCTs from 2018 (April 2023). Ongoing trial registers were searched (WHO ICTRP, ClinicalTrials.gov, April 2023). Eligible studies were randomised controlled trials comparing PIFU with an alternative FU model in adult cancer survivors. Risk of bias assessment was via the Cochrane risk of bias tool-2. Meta-analysis was precluded by clinical heterogeneity and results were reported narratively.

resultsTen RCTs were included (six breast, two colorectal, one endometrial cancer and one melanoma, total n = 1754); all studies had risk of bias concerns, particularly relating to how missing data were handled, and populations were unlikely to be representative. Limited findings in breast cancer suggested that type of FU does not affect recurrence detection or patient-related outcomes, while PIFU may reduce the number of clinic visits. Adding patient-led surveillance to routine FU may increase melanoma detection. Evidence for other types of cancer is too limited to draw firm conclusions.

conclusionsPIFU may be a viable FU model in breast cancer, but further research is needed for other types of cancer and on long-term outcomes. A protocol was registered with PROSPERO (CRD42020181424).

Indexed as

Cancer SurvivorsNeoplasmsAppointments and SchedulesFemaleFollow-Up StudiesHumansRandomized Controlled Trials as Topiccancerpatient-initiated follow-uprandomised controlled trialsystematic review

Identifiers

PMID37602830
PMCPMC10557867

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.