Evidence map›Paper›PMID 37602394›Full record

ArticlePhysiological genomics2023

Mild and moderate chronic hypercapnia elicit distinct transcriptomic responses of immune function in cardiorespiratory nuclei.

Kirstyn J Grams, Suzanne E Neumueller, Gary C Mouradian, Nicholas J Burgraff, Matthew R Hodges, Lawrence Pan, Hubert V Forster

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kirstyn J GramsDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.ORCID 0000-0002-2322-4811
Suzanne E NeumuellerDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Gary C MouradianDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Nicholas J BurgraffCenter for Integrated Brain Research, Seattle Children's Research Institute, Seattle, Washington, United States.ORCID 0000-0001-7986-4247
Matthew R HodgesDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Lawrence PanDepartment of Physical Therapy, Marquette University, Milwaukee, Wisconsin, United States.
Hubert V ForsterDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.ORCID 0000-0002-6228-2942
Medical College of Wisconsin · USMarquette University · US

Funding

Progressive seizure-induced cardiorespiratory dysfunction in a novel mutant rat model of seizure disorderR01HL122358 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HODGES, MATTHEW ROBERT · 2015 to 2024
$4.3M
Physiologic, ventilatory, and CNS transcriptomic response to chronic hypercapnia in goatsF31HL159908 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI GRAMS, KIRSTYN · 2022 to 2022
$38k
Mechanisms of Ventilatory Adaptations to Chronic HypercapniaI01BX003284 · VA · CLEMENT J. ZABLOCKI VA MEDICAL CENTER · PI FORSTER, HUBERT V · 2016 to 2024
–
BLRD VA I01 BX003284NHLBI NIH HHS F31 HL159908NHLBI NIH HHS R01 HL122358
6 · The paper itself

Abstract

Chronic hypercapnia (CH) is a hallmark of respiratory-related diseases, and the level of hypercapnia can acutely or progressively become more severe. Previously, we have shown time-dependent adaptations in steady-state physiology during mild (arterial Pco

Indexed as

HypercapniaTranscriptomeBrainGene Expression ProfilingHumansImmunitycentral chemoreceptionhypercapniaimmune responseRNA sequencing

Identifiers

PMID37602394
PMCPMC11178267
OpenAlexW4386020243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.