Evidence map›Paper›PMID 37602386›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2023

Intranasal insulin treatment partially corrects the altered gene expression profile in the hippocampus of developing rats with perinatal iron deficiency.

Brian J Sandri, Kathleen Ennis-Czerniak, Priya Kanajam, William H Frey, Eric F Lock, Raghavendra B Rao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Brian J SandriDivision of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, United States.ORCID 0000-0003-4935-6502
Kathleen Ennis-CzerniakDivision of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, United States.
Priya KanajamDivision of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, United States.ORCID 0000-0002-5617-2499
William H FreyHealthPartners Center for Memory and Aging, HealthPartners Neurosciences, St. Paul, Minnesota, United States.ORCID 0000-0002-6373-0794
Eric F LockDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States.ORCID 0000-0003-4663-2356
Raghavendra B RaoDivision of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, United States.ORCID 0000-0002-6089-5972
University of Minnesota · USHealthPartners · US

Funding

Detection and Correction of Iron Deficiency Induced Abnormal Brain MetabolismR01HD089989 · NICHD · UNIVERSITY OF MINNESOTA · PI COE, CHRISTOPHER L, GEORGIEFF, MICHAEL K. · 2017 to 2021
$2.7M
Identifying Biomarkers from Multi-source, Multi-way DataR01GM130622 · NIGMS · UNIVERSITY OF MINNESOTA · PI LOCK, ERIC F · 2019 to 2023
$1.5M
NICHD NIH HHS R01 HD089989NIGMS NIH HHS R01 GM130622
6 · The paper itself

Abstract

Perinatal iron deficiency (FeD) targets the hippocampus and leads to long-term cognitive deficits. Intranasal insulin administration improves cognitive deficits in adult humans with Alzheimer's disease and type 2 diabetes and could provide benefits in FeD-induced hippocampal dysfunction. To objective was to assess the effects of intranasal insulin administration intranasal insulin administration on the hippocampal transcriptome in a developing rat model of perinatal FeD. Perinatal FeD was induced using low-iron diet from gestational

Indexed as

Diabetes Mellitus, Type 2Iron DeficienciesAdultAnimalsFemaleHippocampusHumansInsulinIronMechanistic Target of Rapamycin Complex 2PregnancyRatsTranscriptomeInsulinIronMechanistic Target of Rapamycin Complex 2brainhippocampusintranasal insulin treatmentiron deficiencytranscriptome

Identifiers

PMID37602386
PMCPMC10639019
OpenAlexW4386019825

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.