ArticlemicroPublication biology2023
Apoptotic pathway protein expression variance in metal oxide and quantum dot treated HeLa cells.
Article in microPublication biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 3 citations in OpenAlex.
- Interactions between Quantum Dots and G-Actin.International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using the HeLa cell line as a cancerous model, apoptotic protein expression was assessed upon various nanoparticle treatments. Utilizing a known chemotherapeutic agent, cisplatin, as a positive control for induction of apoptosis, several metal oxides (ZnO and CuO) and quantum dots (CdSe/ZnS and InP/ZnS) were investigated for their ability to express apoptotic markers. ZnO, CuO, green CdSe/ZnS, and green InP/ZnS were treated for 24 hours at their IC50 value. Western blot techniques were used to measure protein expression of phosphorylated p53 (ser15), PUMA, and p21 which are involved in signal transduction of apoptosis. CuO, ZnO, and CdSe/ZnS demonstrated considerable p53 activation at 24 hrs compared to the non-treated control. At the IC50 value, CdSe/ZnS quantum dots were the quickest at activating p53 by phosphorylation at the Serine 15 residue. Together, our results provide new insight into the apoptotic mechanism behind these treatments and lead to improved treatments against cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.