Evidence map›Paper›PMID 37602268›Full record

ArticleFrontiers in neurology2023

Structural and functional changes of the cerebellum in temporal lobe epilepsy.

Ge Wang, Xianghe Liu, Min Zhang, Kangrun Wang, Chaorong Liu, Yayu Chen, Wenyue Wu, Haiting Zhao, Bo Xiao, Lily Wan and 1 more

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In one paragraph

Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Imaging insights into temporal lobe epilepsy: an AES-SDM meta-analysis and retrospective cohort study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ge Wang *Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Xianghe Liu *Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Min ZhangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Kangrun WangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Chaorong LiuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Yayu ChenDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Wenyue WuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Haiting ZhaoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Bo XiaoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Lily WanDepartment of Anatomy and Neurobiology, Central South University Xiangya Medical School, Changsha, Hunan, China.
Lili LongDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: This study aimed to comprehensively explore the cerebellar structural and functional changes in temporal lobe epilepsy (TLE) and its association with clinical information. Methods: The SUIT toolbox was utilized to perform cerebellar volume and diffusion analysis. In addition, we extracted the average diffusion values of cerebellar peduncle tracts to investigate microstructure alterations. Seed-based whole-brain analysis was used to investigate cerebellar-cerebral functional connectivity (FC). Subgroup analyses were performed to identify the cerebellar participation in TLE with/without hippocampal sclerosis (HS)/focal-to-bilateral tonic-clonic seizure (FBTCS) and TLE with different lateralization. Results: TLE showed widespread gray matter atrophy in bilateral crusII, VIIb, VIIIb, left crusI, and left VIIIa. Both voxel and tract analysis observed diffusion abnormalities in cerebellar afferent peduncles. Reduced FC between the right crus II and the left parahippocampal cortex was found in TLE. Additionally, TLE showed increased FCs between left lobules VI-VIII and cortical nodes of the dorsal attention and visual networks. Across all patients, decreased FC was associated with poorer cognitive function, while increased FCs appeared to reflect compensatory effects. The cerebellar structural changes were mainly observed in HS and FBTCS subgroups and were regardless of seizure lateralization, while cerebellar-cerebral FC alterations were similar in all subgroups. Conclusion: TLE exhibited microstructural changes in the cerebellum, mainly related to HS and FBTCS. In addition, altered cerebellar-cerebral functional connectivity is associated with common cognitive alterations in TLE.

Indexed as

cerebellar pedunclecerebellumfunctional connectivitymultimodality MRItemporal lobe epilepsy

Identifiers

PMID37602268
PMCPMC10435757

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.