Evidence map›Paper›PMID 37602259›Full record

ArticleFrontiers in neurology2023

Precision medicine in neurodegeneration: the IHI-PROMINENT project.

Ashley Tate, Marc Suárez-Calvet, Mats Ekelund, Sven Eriksson, Maria Eriksdotter, Wiesje M Van Der Flier, Jean Georges, Miia Kivipelto, Milica G Kramberger, Peter Lindgren and 10 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
7.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Review
  6. REAL AD-Validation of a realistic screening approach for early Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 9 institutions in 6 countries.

Ashley TateDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Marc Suárez-CalvetBarcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.
Mats EkelundBioArctic AB, Stockholm, Sweden.
Sven ErikssonBioArctic AB, Stockholm, Sweden.
Maria EriksdotterDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Wiesje M Van Der FlierAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC, location VUmc, Amsterdam, Netherlands.
Jean GeorgesAlzheimer Europe, Luxembourg, Luxembourg.
Miia KivipeltoDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Milica G KrambergerDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Peter LindgrenIHE, The Swedish Institute for Health Economics, Lund, Sweden.
Juan Domingo Gispert LópezBarcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.
Jyrki LötjönenCombinostics Oy, Tampere, Finland.
Sofie PerssonIHE, The Swedish Institute for Health Economics, Lund, Sweden.
Sandra PlaSynapse Research Management Partners SL, Madrid, Spain.
Alina SolomonDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Lennart ThurfjellCombinostics Oy, Tampere, Finland.
Anders WimoDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Bengt WinbladDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Linus JönssonDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
PROMINENT consortium
Karolinska Institutet · SEBioArctic Neuroscience (Sweden) · SEHospital Del Mar · ESSwedish Institute for Health Economics · SEAlzheimer Europe · LUAmsterdam Neuroscience · NLKarolinska University Hospital · SESynapse (Spain) · ESUniversity of Ljubljana · SI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegenerative diseases are one of the most important contributors to morbidity and mortality in the elderly. In Europe, over 14 million people are currently living with dementia, at a cost of over 400 billion EUR annually. Recent advances in diagnostics and approval for new pharmaceutical treatments for Alzheimer's disease (AD), the most common etiology of dementia, heralds the beginning of precision medicine in this field. However, their implementation will challenge an already over-burdened healthcare systems. There is a need for innovative digital solutions that can drive the related clinical pathways and optimize and personalize care delivery. Public-private partnerships are ideal vehicles to tackle these challenges. Here we describe the Innovative Health Initiative (IHI) public-private partnership project PROMINENT that has been initiated by connecting leading dementia researchers, medical professionals, dementia patients and their care partners with the latest innovative health technologies using a precision medicine based digital platform. The project builds upon the knowledge and already implemented digital tools from several collaborative initiatives that address new models for early detection, diagnosis, and monitoring of AD and other neurodegenerative disorders. The project aims to provide support to improvement efforts to each aspect of the care pathway including diagnosis, prognosis, treatment, and data collection for real world evidence and cost effectiveness studies. Ultimately the PROMINENT project is expected to lead to cost-effective care and improved health outcomes.

Indexed as

Alzheimer’s diseasebiomarkersclinical decision supportdementiaprecision medicine

Identifiers

PMID37602259
PMCPMC10433183
OpenAlexW4385494319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.