Clustering molecular dynamics conformations of the CC'-loop of the PD-1 immuno-checkpoint receptor.

Wolfgang Schreiner, Rudolf Karch, Michael Cibena, Lisa Tomasiak, Michael Kenn, Georg Pfeiler

Abstract read

In one paragraph

Article in Computational and structural biotechnology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Molecular dynamics insights into the redox effects on PD-1/PD-L1 and PD-1/PD-L2 interactions.Scientific reports · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wolfgang SchreinerMedical University of Vienna, Center for Medical Data Science, Spitalgasse 23, A-1090, Vienna, Austria.

Rudolf KarchMedical University of Vienna, Center for Medical Data Science, Spitalgasse 23, A-1090, Vienna, Austria.

Michael CibenaMedical University of Vienna, Center for Medical Data Science, Spitalgasse 23, A-1090, Vienna, Austria.

Lisa TomasiakMedical University of Vienna, Center for Medical Data Science, Spitalgasse 23, A-1090, Vienna, Austria.

Michael KennMedical University of Vienna, Center for Medical Data Science, Spitalgasse 23, A-1090, Vienna, Austria.

Georg PfeilerMedical University of Vienna, Department of Obstetrics and Gynecology, Division of General Gynecology and Gynecologic Oncology, Währinger Gürtel 18-20, A-1090, Vienna, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molecular mechanisms within the checkpoint receptor PD-1 are essential for its activation by PD-L1 as well as for blocking such an activation via checkpoint inhibitors. We use molecular dynamics to scrutinize patterns of atomic motion in PD-1 without a ligand. Molecular dynamics is performed for the whole extracellular domain of PD-1, and the analysis focuses on its CC'-loop and some adjacent C

Indexed as

Checkpoint receptorCluster analysisDrug designImmune therapyMolecular dynamicsOncology

Identifiers

PMID37602229

DOI10.1016/j.csbj.2023.07.004

PMCPMC10432919

What OpenQuestion holds

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LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.