ArticleCell genomics2023
Cystatin C is glucocorticoid responsive, directs recruitment of Trem2+ macrophages, and predicts failure of cancer immunotherapy.
Article in Cell genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 34 citations in OpenAlex.
- Medications Influencing Serum Cystatin C Independent of Measured GFR.Journal of the American Society of Nephrology : JASN · 2026Article
- Creatinine muscle index in UK Biobank: comparison with MRI and associations with frailty and mortality.Clinical kidney journal · 2026Article
- Article
- Construction of circadian clock signature for tumor microenvironment in predicting survival of esophageal squamous cell carcinoma.Frontiers in immunology · 2026Article
- Development and validation of a novel hepato-metabolic-renal score nomogram for predicting disease-free survival in head and neck squamous cell carcinoma.Frontiers in oncology · 2026Article
- Deceased kidney donor cystatin C and subsequent recipient measured glomerular filtration rate at one year after transplantation.PloS one · 2026Article
- Sex differences in cardiac risk and kidney function: serum creatinine versus cystatin C.BMC medicine · 2025Article
- Obesity in Cardiorenal syndrome: Management Opportunities and Challenges.Current hypertension reports · 2025Review
- Dynamic screening initiation using 16 plasma protein biomarkers with polygenic risk and PLCOm2012: a precision prevention framework for lung cancer.Journal of translational medicine · 2025Article
- Accuracy of glomerular filtration rate estimates among patients with cancer.British journal of cancer · 2025Observational
- Oligomeric cystatin C supports the immunosuppressive activity of myeloid cells through interaction with inhibitory receptors.Signal transduction and targeted therapy · 2025Article
- Article
- Performance of Creatinine and Cystatin C-Based Equations to Estimate Glomerular Filtration Rate Among Patients With Heart Failure.Circulation. Heart failure · 2025Article
- Characterizing the HLA region's genetic architecture through local heritability and correlation analyses across complex traits in diverse ancestries.Human genetics · 2025Article
- Ten tips for an onco-nephrology clinic.Clinical kidney journal · 2025Review
- Estimation of kidney function in Graves' disease using creatinine and cystatin C.Endocrine connections · 2025Article
- Performance of Creatinine and Cystatin-Based Equations on Estimating Measured GFR in People with Hematological and Solid Cancers.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- Discordance between cystatin C-based and creatinine-based estimated glomerular filtration rate and health outcomes in adults: a systematic review and meta-analysis.Clinical kidney journal · 2025Article
- Immunotherapies for Aging and Age-Related Diseases: Advances, Pitfalls, and Prospects.Research (Washington, D.C.) · 2025Review
- CysC as a predictor of left ventricular remodeling and major adverse cardiovascular events in patients with acute myocardial infarction.Frontiers in cardiovascular medicine · 2025Article
Corrections and comments
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Authors and funding
31 authors at 10 institutions in 8 countries.
Funding
Abstract
Cystatin C (CyC), a secreted cysteine protease inhibitor, has unclear biological functions. Many patients exhibit elevated plasma CyC levels, particularly during glucocorticoid (GC) treatment. This study links GCs with CyC's systemic regulation by utilizing genome-wide association and structural equation modeling to determine CyC production genetics in the UK Biobank. Both CyC production and a polygenic score (PGS) capturing predisposition to CyC production were associated with increased all-cause and cancer-specific mortality. We found that the GC receptor directly targets CyC, leading to GC-responsive CyC secretion in macrophages and cancer cells. CyC-knockout tumors displayed significantly reduced growth and diminished recruitment of TREM2+ macrophages, which have been connected to cancer immunotherapy failure. Furthermore, the CyC-production PGS predicted checkpoint immunotherapy failure in 685 patients with metastatic cancer from combined clinical trial cohorts. In conclusion, CyC may act as a GC effector pathway via TREM2+ macrophage recruitment and may be a potential target for combination cancer immunotherapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.