Evidence map›Paper›PMID 37601821›Full record

ArticleSynthetic biology (Oxford, England)2023

Periplasmic stress contributes to a trade-off between protein secretion and cell growth in

Sivaram Subaya Emani, Anton Kan, Timothy Storms, Shanna Bonanno, Jade Law, Sanhita Ray, Neel S Joshi

Open access · goldAbstract read
In one paragraph

Article in Synthetic biology (Oxford, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Programming cellular condensates for living materials using an intrinsically disordered protein display platform.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Anton KanDepartment of Materials, ETH Zürich, Zürich, Switzerland.
Timothy StormsDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA.
Shanna BonannoDepartment of Bioengineering, Northeastern University, Boston, MA, USA.
Jade LawDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA.
Sanhita RayDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Neel S JoshiDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA.
Northeastern University · USETH Zurich · CHHarvard University · USKarolinska Institutet · SE

Funding

Investigating the role of natural and engineered curli fibers in mediating interactions with the gut epitheliumR01DK110770 · NIDDK · NORTHEASTERN UNIVERSITY · PI JOSHI, NEEL SATISH · 2017 to 2021
$1.9M
NIDDK NIH HHS R01 DK110770
6 · The paper itself

Abstract

Maximizing protein secretion is an important target in the design of engineered living systems. In this paper, we characterize a trade-off between cell growth and per-cell protein secretion in the curli biofilm secretion system of

Indexed as

bacterial secretiongrowth–production trade-offsecretion optimization

Identifiers

PMID37601821
PMCPMC10439730
OpenAlexW4385445035

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.