Evidence map›Paper›PMID 37601695›Full record

ArticleFrontiers in oncology2023

A clinical evaluation of the performance of five commercial artificial intelligence contouring systems for radiotherapy.

Paul J Doolan, Stefanie Charalambous, Yiannis Roussakis, Agnes Leczynski, Mary Peratikou, Melka Benjamin, Konstantinos Ferentinos, Iosif Strouthos, Constantinos Zamboglou, Efstratios Karagiannis

Abstract read
In one paragraph

Article in Frontiers in oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed.

  1. Trial
  2. Review
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  9. Quantifying manual editing time in autocontouring via audit log analysis.Physics and imaging in radiation oncology · 2026
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Changes in Cardiac Function in Patients Receiving Radiation Therapy for Lung Cancer.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Educational Impact of a National Training Webinar on AI-based Automatic Contouring in Radiation Oncology.Journal of cancer education : the official journal of the American Association for Cancer Education · 2026
    Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Paul J DoolanDepartment of Medical Physics, German Oncology Center, Limassol, Cyprus.
Stefanie CharalambousDepartment of Radiation Oncology, German Oncology Center, Limassol, Cyprus.
Yiannis RoussakisDepartment of Medical Physics, German Oncology Center, Limassol, Cyprus.
Agnes LeczynskiDepartment of Radiation Oncology, German Oncology Center, Limassol, Cyprus.
Mary PeratikouDepartment of Radiation Oncology, German Oncology Center, Limassol, Cyprus.
Melka BenjaminDepartment of Radiation Oncology, German Oncology Center, Limassol, Cyprus.
Konstantinos FerentinosDepartment of Radiation Oncology, German Oncology Center, Limassol, Cyprus.
Iosif StrouthosDepartment of Radiation Oncology, German Oncology Center, Limassol, Cyprus.
Constantinos ZamboglouDepartment of Radiation Oncology, German Oncology Center, Limassol, Cyprus.
Efstratios KaragiannisDepartment of Radiation Oncology, German Oncology Center, Limassol, Cyprus.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose/objectives: Auto-segmentation with artificial intelligence (AI) offers an opportunity to reduce inter- and intra-observer variability in contouring, to improve the quality of contours, as well as to reduce the time taken to conduct this manual task. In this work we benchmark the AI auto-segmentation contours produced by five commercial vendors against a common dataset. Methods and materials: The organ at risk (OAR) contours generated by five commercial AI auto-segmentation solutions (Mirada (Mir), MVision (MV), Radformation (Rad), RayStation (Ray) and TheraPanacea (Ther)) were compared to manually-drawn expert contours from 20 breast, 20 head and neck, 20 lung and 20 prostate patients. Comparisons were made using geometric similarity metrics including volumetric and surface Dice similarity coefficient (vDSC and sDSC), Hausdorff distance (HD) and Added Path Length (APL). To assess the time saved, the time taken to manually draw the expert contours, as well as the time to correct the AI contours, were recorded. Results: There are differences in the number of CT contours offered by each AI auto-segmentation solution at the time of the study (Mir 99; MV 143; Rad 83; Ray 67; Ther 86), with all offering contours of some lymph node levels as well as OARs. Averaged across all structures, the median vDSCs were good for all systems and compared favorably with existing literature: Mir 0.82; MV 0.88; Rad 0.86; Ray 0.87; Ther 0.88. All systems offer substantial time savings, ranging between: breast 14-20 mins; head and neck 74-93 mins; lung 20-26 mins; prostate 35-42 mins. The time saved, averaged across all structures, was similar for all systems: Mir 39.8 mins; MV 43.6 mins; Rad 36.6 min; Ray 43.2 mins; Ther 45.2 mins. Conclusions: All five commercial AI auto-segmentation solutions evaluated in this work offer high quality contours in significantly reduced time compared to manual contouring, and could be used to render the radiotherapy workflow more efficient and standardized.

Indexed as

AIbreastcontouringhead and necklungprostateradiotherapy

Identifiers

PMID37601695
PMCPMC10436522

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.