Evidence map›Paper›PMID 37601415›Full record

ArticleResults in chemistry2022

Ureas derived from camphor and fenchone reveal enantiomeric preference of human soluble epoxide hydrolase.

Vladimir Burmistrov, Christophe Morisseau, Dmitry Pitushkin, Robert R Fayzullin, Dmitry Karlov, Andrey Vernigora, Yaroslav Kuznetsov, Saeef M H Abbas, Gennady M Butov, Bruce D Hammock

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Results in chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Vladimir BurmistrovDepartment of Entomology and Nematology, and Comprehensive Cancer Center, University of California, Davis, CA, 95616, USA.
Christophe MorisseauDepartment of Entomology and Nematology, and Comprehensive Cancer Center, University of California, Davis, CA, 95616, USA.
Dmitry PitushkinDepartment of Chemistry, Technology and Equipment of Chemical Industry, Volzhsky Polytechnic Institute (branch) Volgograd State Technical University, Volzhsky, 404121, Russia.
Robert R FayzullinArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, 8 Arbuzov Street, Kazan, 420088, Russia.
Dmitry KarlovSkolkovo Institute of Science and Technology, Skolkovo Innovation Center, Moscow, 143026, Russia.
Andrey VernigoraDepartment of Organic Chemistry, Volgograd State Technical University, Volgograd, 400005, Russia.
Yaroslav KuznetsovDepartment of Chemistry, Technology and Equipment of Chemical Industry, Volzhsky Polytechnic Institute (branch) Volgograd State Technical University, Volzhsky, 404121, Russia.
Saeef M H AbbasDepartment of Chemistry, Technology and Equipment of Chemical Industry, Volzhsky Polytechnic Institute (branch) Volgograd State Technical University, Volzhsky, 404121, Russia.
Gennady M ButovDepartment of Chemistry, Technology and Equipment of Chemical Industry, Volzhsky Polytechnic Institute (branch) Volgograd State Technical University, Volzhsky, 404121, Russia.
Bruce D HammockDepartment of Entomology and Nematology, and Comprehensive Cancer Center, University of California, Davis, CA, 95616, USA.
Volgograd State Technical University · RUUniversity of California, Davis · USA.E. Arbuzov Institute of Organic and Physical Chemistry · RUSkolkovo Institute of Science and Technology · RU

Funding

Supplement for bioactive lipids as effectors and indicators of the deleterious effects of human healthR35ES030443 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MORISSEAU, CHRISTOPHE HP · 2019 to 2025
$5.8M
NIEHS NIH HHS R35 ES030443
6 · The paper itself

Abstract

The soluble epoxide hydrolase (sEH) is a potential target to treat cardiovascular, renal and neuronal diseases. A series of sEH inhibitors containing naturally occurring lipophilic groups (originating from camphor and fenchone) were developed. Inhibitory potency ranging from 0.7 nM to 6.47 μM was obtained. It was discovered that ureas derived from L-camphor were more active against sEH (2.3-fold average) than the corresponding analogues derived from D-camphor indicating enantiomeric preference of sEH. Ureas derived from fenchone possess lower activity against sEH (ca. 80-fold on average) than their camphor-derived analogs due to the specific structure of the lipophilic fragment and show less enantiomeric preference (1.75-fold on average). Moreover, fenchone-derived ureas show no consistency in enantiomeric preference.

Indexed as

camphorepoxyeicosatrienoic acidsfenchoneinhibitorsoluble epoxide hydrolaseurea

Identifiers

PMID37601415
PMCPMC10438916
OpenAlexW4309332268

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.