ArticleScandinavian journal of statistics, theory and applications2023
Generalizing the information content for stepped wedge designs: A marginal modeling approach.
Article in Scandinavian journal of statistics, theory and applications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Analysis of Stepped-Wedge Cluster Randomized Trials: A Tutorial Using Marginal Models.Statistics in medicine · 2026Article
- The relative efficiency of staircase and stepped wedge cluster randomised trial designs.Statistical methods in medical research · 2025Article
- Reconsidering stepped wedge cluster randomized trial designs with implementation periods: Fewer sequences or the parallel-group design with baseline and implementation periods are potentially more efficient.Clinical trials (London, England) · 2024Article
- Optimal designs using generalized estimating equations in cluster randomized crossover and stepped wedge trials.Statistical methods in medical research · 2024Article
- The impact of iterative removal of low-information cluster-period cells from a stepped wedge design.BMC medical research methodology · 2023Article
- Power analyses for stepped wedge designs with multivariate continuous outcomes.Statistics in medicine · 2023Article
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Authors and funding
6 authors.
Funding
Abstract
Stepped wedge trials are increasingly adopted because practical constraints necessitate staggered roll-out. While a complete design requires clusters to collect data in all periods, resource and patient-centered considerations may call for an incomplete stepped wedge design to minimize data collection burden. To study incomplete designs, we expand the metric of information content to discrete outcomes. We operate under a marginal model with general link and variance functions, and derive information content expressions when data elements (cells, sequences, periods) are omitted. We show that the centrosymmetric patterns of information content can hold for discrete outcomes with the variance-stabilizing link function. We perform numerical studies under the canonical link function, and find that while the patterns of information content for cells are approximately centrosymmetric for all examined underlying secular trends, the patterns of information content for sequences or periods are more sensitive to the secular trend, and may be far from centrosymmetric.
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