Evidence map›Paper›PMID 37601252›Full record

ArticlePeerJ2023

Hub gene associated with prognosis in bladder cancer is a novel therapeutic target.

Dengpan Fang, Yuanqiao He, Yun Yi, Jiaqi Mei, Cundong Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Dengpan FangDepartment of Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Yuanqiao HeCenter of Laboratory Animal Science, Nanchang University,, Nanchang, China.
Yun YiThe Second Affiliated Hospital of Nanchang University, Nanchang, China.
Jiaqi MeiThe First Clinical Medical College, Nanchang University, Nanchang, China.
Cundong LiuDepartment of Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Nanchang University · CNThird Affiliated Hospital of Southern Medical University · CNWuhan Sixth Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Bladder cancer is a clinical and social conundrum due to its high incidence and recurrence rate. It is urgent to find new targets for the diagnosis and treatment of bladder cancer and improve the prognosis and survival rate of bladder cancer patients. We sought a prognosis-related gene, built related models of evaluated bladder cancer and identified the function of the hub gene in bladder cancer. Methods: We downloaded the data of bladder cancer patients from the TCGA database, and used differentially expressed genes (DEGs), copy number variation (CNV) and survival analysis to scan the hub genes associated with prognosis in bladder cancer. Then, multi-factor cox regression was used to obtain the bladder cancer prognosis correlation model. Then, we analyzed the relationship between the expression of hub gene and immune microenvironment of bladder cancer. The relationship between the expression of hub gene and prognosis in bladder cancer patients was verified by immunohistochemistry. Cell proliferation assay and drug sensitivity test Results: In bladder cancer, we screened seven hub genes ( Conclusions: In this study, a prognostic model with seven hub genes has provided great help for the prognosis prediction of bladder cancer patients. And

Indexed as

Carcinoma, Transitional CellUrinary Bladder NeoplasmsAnimalsDNA Copy Number VariationsHumansMicePrognosisTumor MicroenvironmentUrinary BladderBladder cancerHub genePrognosis

Identifiers

PMID37601252
PMCPMC10439716
OpenAlexW4385874759

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.