ArticleTherapeutic advances in chronic disease2023
Association between serum trace elements and sleep disturbance in patients with decompensated cirrhosis.
Article in Therapeutic advances in chronic disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- Association Between Trace Elements and Sleep Duration in Patients with Type 2 Diabetes Mellitus: Evidence from a Kurdish Population in Western Iran.Biological trace element research · 2026Article
- Role of toxic and essential elements in sleep duration of patients with cardiovascular diseases.Scientific reports · 2025Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
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Abstract
Background: Sleep disturbance and trace elements imbalance are common features in patients with decompensated cirrhosis, partially sharing similar mechanistic contributors and linking to adverse outcomes. However, there is a paucity of data concerning their relationship. Objectives: To investigate the association between serum trace elements levels and sleep quality in the context of cirrhosis. Design: Cross-sectional study. Methods: We consecutively enrolled 160 patients with decompensated cirrhosis. The sleep disturbance was determined by the Pittsburgh Sleep Quality Index (PSQI > 5). Serum trace elements [magnesium, calcium, iron, copper (Cu), zinc (Zn), lead, and manganese] was measured by inductively coupled plasma mass spectrometry. Association of examined trace elements levels and sleep disturbance was analyzed by multiple linear (global PSQI scores) and multivariate logistic (dichotomized PSQI categories) regression models, respectively. Results: In total, 91 patients (56.88%) represented PSQI-defined sleep disturbance, characterized by female preponderance, lower body mass index levels, and higher serum Cu levels (all Conclusion: Our findings implied an association between higher CZr and the presence of sleep disturbance in patients with decompensated cirrhosis.
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