ArticleFrontiers in immunology2023
Higher systemic immune-inflammation index and systemic inflammation response index levels are associated with stroke prevalence in the asthmatic population: a cross-sectional analysis of the NHANES 1999-2018.
Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 1 of them a synthesis that pooled it.
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97 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of systemic immune-inflammation index with type 2 diabetes mellitus and its prognostic significance: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Relationship Between Neutrophil Count and 90-Day Outcomes and Effect of Dual Antiplatelet Therapy in Patients With Acute Ischemic Stroke or Transient Ischemic Attack: A Post Hoc Analysis of the INSPIRES Trial.Journal of the American Heart Association · 2025Trial
- CRP-albumin-lymphocyte index and multisystem diseases: a phenome-wide Mendelian randomization study.Molecular genetics and genomics : MGG · 2026Article
- Predictive Value of Composite Inflammatory Markers for Stroke Prognosis: A Prospective Cohort Study.Annals of clinical and translational neurology · 2026Article
- Targeting the Fra2/LCN2 axis attenuates PMRedox biology · 2026Article
- The impact of obesity-related anthropometric indices on diabetic foot ulcer and mortality: analysis of a nationally representative sample.Hormones (Athens, Greece) · 2026Article
- Association of cumulative exposure and dynamic change patterns of metabolic syndrome score with cardiometabolic multimorbidity progression among middle-aged and older Chinese adults: a longitudinal analysis based on CHARLS.Cardiovascular diabetology. Endocrinology reports · 2026Article
- A clinician-oriented machine learning model for adult asthma exacerbation prediction: comparative analysis of nine algorithms.Journal of thoracic disease · 2026Article
- Associations of the Endothelial Activation and Stress Index with breast cancer prevalence and mortality based on NHANES 2001 to 2018.Medicine · 2026Article
- Association between systemic immune-inflammation index and urinary incontinence: Evidence from the National Health and Nutrition Examination Survey.The Journal of international medical research · 2026Article
- Article
- Blood glucose mediation of the association between SIRI and mortality in T2DM complicated with ischemic stroke.Scientific reports · 2026Article
- Systemic immune-inflammation Index and blood pressure control are independent and interactive predictors of atrial fibrillation recurrence after ablation.Frontiers in cardiovascular medicine · 2026Article
- Impact of systemic immune-inflammation index and systemic inflammation response index on all-cause and cause-specific mortality: a community-based cohort study.Frontiers in medicine · 2026Article
- High systolic blood pressure and stroke: evidence from the NHANES 1999-2023 and global burden of disease 2021.Experimental biology and medicine (Maywood, N.J.) · 2026Article
- Is it possible to use complete blood collection based systemic inflammatory indices as potential biomarkers for chronic spontaneous urticaria.Frontiers in immunology · 2026Article
- Comparative value of novel inflammatory indices in predicting incident carotid atherosclerosis: SIRI outperforms other markers in a general population.Frontiers in cardiovascular medicine · 2026Article
- Hemoglobin-to-Red cell distribution width ratio and asthma risk: cross-population validation and vitamin D mediation analysis.Frontiers in allergy · 2026Article
- Risk Factors for Diabetic Retinopathy Change With Diabetes Duration: Synergistic Effect of Long Duration and Anemia.Journal of diabetes research · 2026Article
- Systemic immune-inflammation index and systemic inflammation response index as predictors of mortality in participants with and without cancer.The Journal of international medical research · 2026Article
37 more citing papers are in PubMed but not listed here.
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8 authors.
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Abstract
Background: Significant evidence suggests that asthma might originate from low-grade systemic inflammation. Previous studies have established a positive association between the systemic immune-inflammation index (SII) and the systemic inflammation response index (SIRI) levels and the risk of stroke. However, it remains unclear whether SII, SIRI and the prevalence of stroke are related in individuals with asthma. Methods: The present cross-sectional study used data from the National Health and Nutrition Examination Survey (NHANES) conducted between 1999 and 2018. SII was calculated using the following formula: (platelet count Results: Between 1999 and 2018, 5,907 NHANES participants with asthma were identified, of which 199 participants experienced a stroke, while the remaining 5,708 participants had not. Spearman rank correlation analysis indicated that neither SII nor SIRI levels exhibited any significant correlation with the baseline characteristics of the participants (r<0.1). ROC curves were used to determine the optimal cut-off values for SII and SIRI levels to classify participants into low- and high-level groups. Higher SII and SIRI levels were associated with a higher prevalence of stroke, with ORs of 1.80 (95% CI, 1.18-2.76) and 2.23 (95% CI, 1.39-3.57), respectively. The predictive value of SIRI (AUC=0.618) for stroke prevalence was superior to that of SII (AUC=0.552). Furthermore, the clinical model demonstrated good predictive value (AUC=0.825), with a sensitivity of 67.1% and specificity of 87.7%. Conclusion: In asthmatics, higher levels of SII and SIRI significantly increased the prevalence of stroke, with its association being more pronounced in individuals with coexisting obesity and hyperlipidaemia. SII and SIRI are relatively stable novel inflammatory markers in the asthmatic population, with SIRI having a better predictive value for stroke prevalence than SII.
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