Evidence map›Paper›PMID 37600822›Full record

ReviewFrontiers in immunology2023

Nanoparticle-based drug delivery systems to enhance cancer immunotherapy in solid tumors.

Jiaxin Zhang, Siyuan Wang, Daidi Zhang, Xin He, Xue Wang, Huiqiong Han, Yanru Qin

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jiaxin ZhangDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Siyuan WangDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Daidi ZhangDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xin HeDepartment of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xue WangAcademy of Medical Science, School of Basic Medical Science, Zhengzhou University, Zhengzhou, China.
Huiqiong HanDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yanru QinDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
First Affiliated Hospital of Zhengzhou University · CNZhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunotherapy has developed rapidly in solid tumors, especially in the areas of blocking inhibitory immune checkpoints and adoptive T-cell transfer for immune regulation. Many patients benefit from immunotherapy. However, the response rate of immunotherapy in the overall population are relatively low, which depends on the characteristics of the tumor and individualized patient differences. Moreover, the occurrence of drug resistance and adverse reactions largely limit the development of immunotherapy. Recently, the emergence of nanodrug delivery systems (NDDS) seems to improve the efficacy of immunotherapy by encapsulating drug carriers in nanoparticles to precisely reach the tumor site with high stability and biocompatibility, prolonging the drug cycle of action and greatly reducing the occurrence of toxic side effects. In this paper, we mainly review the advantages of NDDS and the mechanisms that enhance conventional immunotherapy in solid tumors, and summarize the recent advances in NDDS-based therapeutic strategies, which will provide valuable ideas for the development of novel tumor immunotherapy regimen.

Indexed as

Drug-Related Side Effects and Adverse ReactionsNanoparticlesNeoplasmsHumansImmunotherapyNanoparticle Drug Delivery SystemNanoparticle Drug Delivery SystemEPR effectimmunogenic cell deathimmunotherapynanodrug delivery systemsnanoparticlessolid tumorstumor microenvironment

Identifiers

PMID37600822
PMCPMC10435760
OpenAlexW4385520152

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.