Evidence map›Paper›PMID 37600690›Full record

ArticleFrontiers in endocrinology2023

Hyun-Ju Cho, Fatih Gurbuz, Maria Stamou, Leman Damla Kotan, Stephen Matthew Farmer, Sule Can, Miranda Faith Tompkins, Jamala Mammadova, S Ayca Altincik, Cumali Gokce and 9 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Genetics of Idiopathic Hypogonadotropic HypogonadismJournal of clinical research in pediatric endocrinology · 2026
    Review
  3. Article
  4. Article
  5. De novo rare EMX2 variants lead to idiopathic hypogonadotropic hypogonadism.Genetics in medicine : official journal of the American College of Medical Genetics · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 2 countries.

Hyun-Ju ChoCellular and Developmental Neurobiology Section, National Institute of Neurologic Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States.
Fatih GurbuzDivision of Pediatric Endocrinology, Faculty of Medicine, Cukurova University, Adana, Türkiye.
Maria StamouHarvard Reproductive Sciences Center, The Reproductive Endocrine Unit and The Endocrine Unit of the Department of Medicine, Massachusetts General Hospital, Boston, MA, United States.
Leman Damla KotanDivision of Pediatric Endocrinology, Faculty of Medicine, Cukurova University, Adana, Türkiye.
Stephen Matthew FarmerCellular and Developmental Neurobiology Section, National Institute of Neurologic Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States.
Sule CanDivision of Pediatric Endocrinology, İzmir Tepecik Training and Research Hospital, Health Sciences University, İzmir, Türkiye.
Miranda Faith TompkinsCellular and Developmental Neurobiology Section, National Institute of Neurologic Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States.
Jamala MammadovaDivision of Pediatric Endocrinology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Türkiye.
S Ayca AltincikDivision of Pediatric Endocrinology, Faculty of Medicine, Pamukkale University, Denizli, Türkiye.
Cumali GokceDivision of Endocrinology, Faculty of Medicine, Mustafa Kemal University, Hatay, Türkiye.
Gonul CatliDivision of Pediatric Endocrinology, İzmir Tepecik Training and Research Hospital, Health Sciences University, İzmir, Türkiye.
Fuat BugrulDivision of Pediatric Endocrinology, Faculty of Medicine, Selcuk University, Konya, Türkiye.
Keenan BartlettCellular and Developmental Neurobiology Section, National Institute of Neurologic Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States.
Ihsan TuranDivision of Pediatric Endocrinology, Faculty of Medicine, Cukurova University, Adana, Türkiye.
Ravikumar BalasubramanianHarvard Reproductive Sciences Center, The Reproductive Endocrine Unit and The Endocrine Unit of the Department of Medicine, Massachusetts General Hospital, Boston, MA, United States.
Bilgin YukselDivision of Pediatric Endocrinology, Faculty of Medicine, Cukurova University, Adana, Türkiye.
Stephanie B SeminaraHarvard Reproductive Sciences Center, The Reproductive Endocrine Unit and The Endocrine Unit of the Department of Medicine, Massachusetts General Hospital, Boston, MA, United States.
Susan WrayCellular and Developmental Neurobiology Section, National Institute of Neurologic Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States.
A Kemal TopalogluDepartment of Pediatrics, Division of Pediatric Endocrinology, University of Mississippi Medical Center, Jackson, MS, United States.
National Institutes of Health · USCukurova University · TRMassachusetts General Hospital · USIzmir University · TRMustafa Kemal University · TROndokuz Mayıs University · TRPamukkale University · TRSelçuk University · TR

Funding

The Massachusetts General Hospital Harvard Center for Reproductive MedicineP50HD104224 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI TALKOWSKI, MICHAEL E · 2021 to 2025
$7.8M
Dissection of the Molecular Basis of Pleiotropy Between GnRH Neuronal Development and Cranial Suture FusionR01DE031452 · NIDCR · MASSACHUSETTS GENERAL HOSPITAL · PI Erica Ellen Davis, Stephanie Beth Seminara · 2022 to 2026
$3.9M
Integrative Approaches to Decipher Genetic Determinants of Disease Penetrance in Prokineticin 2 Pathway Related Human Reproductive DisordersR01HD096324 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI BALASUBRAMANIAN, RAVIKUMAR · 2018 to 2022
$1.7M
Deciphering the Role of Copy Number Variants in Neuroendocrine Disorders of InfertilityF32HD108873 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI STAMOU, MARIA · 2022 to 2024
$233k
NICHD NIH HHS F32 HD108873NICHD NIH HHS P50 HD104224NICHD NIH HHS R01 HD096324NIDCR NIH HHS R01 DE031452
6 · The paper itself

Abstract

Idiopathic hypogonadotropic hypogonadism (IHH) is characterized by the absence of pubertal development and subsequent impaired fertility often due to gonadotropin-releasing hormone (GnRH) deficits. Exome sequencing of two independent cohorts of IHH patients identified 12 rare missense variants in

Indexed as

BrainHypogonadismMutation, MissensePOU Domain FactorsAnimalsGonadotropin-Releasing HormoneHumansMiceGonadotropin-Releasing HormonePOU6F2 protein, humanPOU Domain FactorsGnRHidiopathic hypogonadotropic hypogonadismPOU6f2 isoform1pubertytranscription

Identifiers

PMID37600690
PMCPMC10436210
OpenAlexW4385450771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.