ReviewWellcome open research2023
Severe anaemia, iron deficiency, and susceptibility to invasive bacterial infections.
Review in Wellcome open research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Liberal transfusion strategies reduce sepsis risk and improve neurological recovery in acute brain injury: an updated systematic review and meta-analysis.Critical care (London, England) · 2025Pooled it
- Evaluating the Role of School-Based Weekly Iron-Folic Acid Supplementation in Shaping Common Morbidity and Growth Outcomes Among Adolescent Girls: Evidence From a Cluster-Randomized Controlled Trial in Central Ethiopia Region.Maternal & child nutrition · 2026Trial
- The Gut-Iron-Immune Axis in Severe Anaemia and Bacteraemia.Nutrients · 2026Review
- Article
- Prognostic role of anaemia in maxillofacial space infections: a prospective clinical cohort study.Oral and maxillofacial surgery · 2026Article
- Association of Anemia Severity with Distinct Microbial and Inflammatory Signatures in Patients Receiving Vancomycin.Healthcare (Basel, Switzerland) · 2026Article
- The effect of Guipiheji (Guipi Mixture) combined with ferrous succinate tablets on improving iron deficiency anemia.Frontiers in medicine · 2026Article
- Prioritization of antimicrobial resistance surveillance of gram-negative pathogens - a stacked modelling approach.Wellcome open research · 2026Article
- Iron deficiency and vaccine efficacy: A mini-review of immunological interplay and evidence across vaccine types.Human vaccines & immunotherapeutics · 2025Review
- Gut bacterial dysbiosis in pediatric severe malaria associates with post-discharge mortality.Nature communications · 2025Article
- Dual-species proteomics and targeted intervention of animal-pathogen interactions.Journal of advanced research · 2025Article
- Spatial distribution of malaria among under-five children and associated factors in Tanzania: a spatial and multilevel analysis.Malaria journal · 2025Article
- Iron deficiency and infection risk in Danish blood donors.Transfusion · 2025Article
- Article
- Paediatric anaemia in rural Kenya and the role of travel time to emergency care services.Frontiers in epidemiology · 2025Article
- Key players in the regulation of iron homeostasis at the host-pathogen interface.Frontiers in immunology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
Severe anaemia and invasive bacterial infections remain important causes of hospitalization and death among young African children. The emergence and spread of antimicrobial resistance demand better understanding of bacteraemia risk factors to inform prevention strategies. Epidemiological studies have reported an association between severe anaemia and bacteraemia. In this review, we explore evidence that severe anaemia is associated with increased risk of invasive bacterial infections in young children. We describe mechanisms of iron dysregulation in severe anaemia that might contribute to increased risk and pathogenesis of invasive bacteria, recent advances in knowledge of how iron deficiency and severe anaemia impair immune responses to bacterial infections and vaccines, and the gaps in our understanding of mechanisms underlying severe anaemia, iron deficiency, and the risk of invasive bacterial infections.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.