Evidence map›Paper›PMID 37600340›Full record

ArticleOncology letters2023

Unusual localization and clinical presentation of primary central nervous system extranodal marginal zone B‑cell lymphoma: A case report.

Vincenzo Fiorentino, Cristina Pizzimenti, Francesco Pierconti, Maria Lentini, Antonio Ieni, Maria Caffo, Filippo Angileri, Giovanni Tuccari, Guido Fadda, Maurizio Martini and 1 more

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Oncology letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Vincenzo FiorentinoDepartment of Human Pathology in Adult and Developmental Age 'Gaetano Barresi', Pathology Section, University Hospital 'G. Martino', University of Messina, I-98125 Messina, Italy.
Cristina PizzimentiDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University Hospital 'G. Martino', University of Messina, I-98125 Messina, Italy.
Francesco PiercontiInstitute of Pathology, Division of Anatomic Pathology and Histology, A. Gemelli-Scientific Institute for Research, Hospitalization and Healthcare University Hospital Foundation, I-00168 Rome, Italy.
Maria LentiniDepartment of Human Pathology in Adult and Developmental Age 'Gaetano Barresi', Pathology Section, University Hospital 'G. Martino', University of Messina, I-98125 Messina, Italy.
Antonio IeniDepartment of Human Pathology in Adult and Developmental Age 'Gaetano Barresi', Pathology Section, University Hospital 'G. Martino', University of Messina, I-98125 Messina, Italy.
Maria CaffoDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, Section of Neurosurgery, University Hospital 'G. Martino', I-98125 Messina, Italy.
Filippo AngileriDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, Section of Neurosurgery, University Hospital 'G. Martino', I-98125 Messina, Italy.
Giovanni TuccariDepartment of Human Pathology in Adult and Developmental Age 'Gaetano Barresi', Pathology Section, University Hospital 'G. Martino', University of Messina, I-98125 Messina, Italy.
Guido FaddaDepartment of Human Pathology in Adult and Developmental Age 'Gaetano Barresi', Pathology Section, University Hospital 'G. Martino', University of Messina, I-98125 Messina, Italy.
Maurizio MartiniDepartment of Human Pathology in Adult and Developmental Age 'Gaetano Barresi', Pathology Section, University Hospital 'G. Martino', University of Messina, I-98125 Messina, Italy.
Luigi Maria LaroccaDepartment of Medicine and Surgery, Unicamillus, Saint Camillus International University of Health Sciences, International Medical University in Rome, I-00131 Rome, Italy.
University of Messina · ITAgostino Gemelli University Polyclinic · ITSaint Camillus International University of Health and Medical Sciences · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary central nervous system (CNS) extranodal marginal zone B-cell lymphoma (MZBL) is a rare low-grade non-Hodgkin lymphoma, characterised predominantly by small B cells, plasma cells, monocytoid cells and scattered large immunoblasts. Primary CNS MZBL is a slow-growing tumour that remains localised and is characterised by an excellent clinical prognosis. The present study describes the case of a 48-year-old HIV-negative female patient with a history of head trauma 1 year prior, who presented with worsening neurological symptoms and a magnetic resonance imaging finding of a ~3-cm extra-axial mass within the left lateral ventricle. From histopathology and immunohistochemistry, the lesion was diagnosed as a CNS MZBL; as no other primary lesions were found, the base of the choroid plexuses of the left lateral ventricle was considered the primary site. To the best of our knowledge, the current case is the first study to report on primary CNS MZBL arising in this anatomical site and paves the way for further studies on the role of chronic inflammation (in the present case resulting from trauma) in the pathogenesis not only of primary CNS MZBL but also of lymphoma in general. Additionally, this report could serve as a starting point for studies analysing the role of meningothelial cells in the pathogenesis of primary CNS MZBL.

Indexed as

B cellcentral nervous system lymphomachoroid plexusextranodal marginal zone lymphomamarginal zone B-cell lymphomas

Identifiers

PMID37600340
PMCPMC10436157
OpenAlexW4385579585

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.