ArticleAnnals of surgery open : perspectives of surgical history, education, and clinical approaches2022
Breast-Conserving Surgery or Mastectomy?: Impact on Survival.
Article in Annals of surgery open : perspectives of surgical history, education, and clinical approaches, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 4 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Impact of Surgical Approach on Survival and Recurrence in Borderline and Malignant Phyllodes Tumours: A Systematic Review and Meta-Analysis.ANZ journal of surgery · 2026Pooled it
- Breast conservation versus mastectomy for metaplastic breast cancer: A systematic review and meta-analysis.Asia-Pacific journal of clinical oncology · 2025Pooled it
- Pooled it
- Quantification of breast lymphoedema following conservative breast cancer treatment: a systematic review.Journal of cancer survivorship : research and practice · 2023Pooled it
- Survival after breast-conserving surgery and radiotherapy versus mastectomy: propensity score analyses within a randomized anaesthesiology trial.The British journal of surgery · 2026Trial
- Scaffold-based breast conserving surgery in patients with non-malignant breast lesions: long-term follow-up of a first-in-human pilot study on the REGENERA™ biomimetic breast implant.Breast cancer (Tokyo, Japan) · 2026Trial
- Comparison of four breast lymphoedema patient reported outcome measures in women following breast conserving surgery and radiotherapy: examination of frequencies of symptoms and measurement properties.Breast cancer (Tokyo, Japan) · 2026Article
- Artificial intelligence-assisted triage of screening mammograms following breast-conserving therapy: a comparative simulation study.La Radiologia medica · 2026Article
- Omission of intraoperative frozen section in sentinel lymph node biopsy for early breast cancer: impact on survival outcomes.Gland surgery · 2026Article
- Chest Wall Perforator Flaps in Oncoplastic Breast Surgery: A Series of 157 Consecutive Cases at the Paris Breast Center.Annals of surgical oncology · 2026Article
- Associations Between Health Information Sources, Sociodemographic and Clinical Characteristics, and Decision-Making Among Women with Early-Stage Breast Cancer.Research square · 2026Article
- Aesthetic Outcomes and Patient-Reported Outcomes of Volume Replacement (Chest Wall Perforator Flaps) versus Volume Displacement: An Observational Study.Aesthetic plastic surgery · 2026Observational
- Inhibition of PTCH1 drug efflux activity enhances chemotherapy efficacy against triple negative breast cancers.Translational oncology · 2026Article
- Retrospective study on the magnetic resonance imaging integration rate of acellular dermal matrix and complications after breast-conserving surgery plus radiotherapy.World journal of surgical oncology · 2026Article
- Oncoplastic Breast Surgery: Bridging Oncological Safety and Aesthetic Excellence in the Era of Precision Surgery.Cureus · 2026Review
- Breast cancer mortality among women who have attended BreastScreen Norway, 1996-2023.Breast cancer research : BCR · 2026Article
- Adjuvant radiotherapy and survival in patients with malignant phyllode tumors: a population-based retrospective study.Breast cancer (Tokyo, Japan) · 2026Article
- AI-based planning for DIEAP flap procedures: exploring foundation models for artery perforators analysis.Frontiers in medicine · 2026Article
- Radiological and Histopathological Predictors of Survival in Neuroendocrine Differentiated Breast Cancer: A Comparative Analysis with NS-IDC.Breast cancer (Dove Medical Press) · 2026Article
- Dissecting autonomy in a resource-constrained setting: a descriptive qualitative study of women's decisions on the surgical treatment of early breast cancer in northern Sri Lanka.Sexual and reproductive health matters · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The early randomized controlled trials revealed no differences in survival between breast-conserving surgery (BCS) and mastectomy. However, breast cancer treatment has undergone changes, and the results of recent population-based registry studies suggest superior long-term survival after BCS. To explore the current evidence, a systematic review and meta-ana lysis of population-based observational studies from 2010 and onward was conducted. Methods: A literature search was conducted in the PubMed, Embase, and Cochrane databases to identify relevant literature. Keywords included "mastectomy," "breast conserving surgery," and "survival." The identified studies were narratively reviewed and effect sizes (hazard ratios [HRs]) for overall (OS) and breast cancer-specific survival (BCSS) were combined with random-effects models. Results: A total of 30 reports were included in the review, and results from 25 studies were included in the meta-analyses. Compared with mastectomy, BCS was associated with better OS (HR = 1.34 [1.20-1.51]; N = 1,311,600) and BCSS (HR = 1.38 [1.29-1.47]; N = 494,267). Selected subgroups of patients, based on lymph node status, age (<50 years/≥50 years), and radiation therapy after mastectomy (±), all showed better overall survival after BCS. The number (range 4-12) and type of prognostic variables adjusted for in the survival analyses of the studies did not statistically significantly moderate the differences in survival between BCS and mastectomy. Conclusions: The combined findings from large population-based studies indicate that BCS is associated with survival benefit compared with mastectomy, suggesting that BCS be the recommended treatment of early breast cancer (T1-2N0-1M0) if a radical lumpectomy can be performed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.