Evidence map›Paper›PMID 37599332›Full record

ArticleInternational journal of oral science2023

Atp6i deficient mouse model uncovers transforming growth factor-β1 /Smad2/3 as a key signaling pathway regulating odontoblast differentiation and tooth root formation.

Jue Wang, Abigail McVicar, Yilin Chen, Hong-Wen Deng, Zhihe Zhao, Wei Chen, Yi-Ping Li

Abstract read
In one paragraph

Article in International journal of oral science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jue WangDepartment of Pathology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Abigail McVicarDivision in Cellular and Molecular Medicine, Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, Tulane University, New Orleans, LA, USA.
Yilin ChenDivision in Cellular and Molecular Medicine, Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, Tulane University, New Orleans, LA, USA.
Hong-Wen DengTulane Center of Biomedical Informatics and Genomics, Deming Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA.
Zhihe ZhaoState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Wei ChenDepartment of Pathology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. wchen18@tulane.edu.
Yi-Ping LiDepartment of Pathology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. yli81@tulane.edu.

Funding

Dental Academic Research Training Program (DART)T90DE022736 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Amjad Javed · 2012 to 2026
$6.7M
Inhibiting Periodontitis by Targeting Cathepsin K and Attenuating TLR SignalingR01DE023813 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LI, YI-PING · 2014 to 2023
$3.9M
Mechanistic basis of the role of Cbx3 in negatively regulating osteoclast differentiation through epigenetic modificationR01AR075735 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LI, YI-PING · 2019 to 2024
$2.4M
Cbfβ mediates articular cartilage regeneration and repair in agingR01AG056438 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHEN, WEI · 2019 to 2023
$2.1M
Gα13 signaling attenuates periodontal inflammation and alveolar bone loss in the mouse model of age-associated periodontitisR01DE028264 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LI, YI-PING · 2018 to 2022
$1.8M
Characterizing the negative signaling in dendritic cells and macrophages to attenuate inflammation and bone destruction in Rheumatoid arthritisR01AR074954 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LI, YI-PING · 2020 to 2024
$1.6M
Characterizing the mechanism by which endogenous negative regulators of osteoclasts control bone homeostasis under physiological and pathological conditions in mouse modelsR01AR070135 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHEN, WEI · 2017 to 2021
$1.6M
Cbfβ mediates articular cartilage regeneration and repair in agingR56AG056438 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHEN, WEI · 2017 to 2017
$371k
NIAMS NIH HHS R01 AR070135NIAMS NIH HHS R01 AR074954NIAMS NIH HHS R01 AR075735NIA NIH HHS R01 AG056438NIA NIH HHS R56 AG056438NIDCR NIH HHS R01 DE023813NIDCR NIH HHS R01 DE028264NIDCR NIH HHS T90 DE022736
6 · The paper itself

Abstract

The biomolecular mechanisms that regulate tooth root development and odontoblast differentiation are poorly understood. We found that Atp6i deficient mice (Atp6i

Indexed as

OdontoblastsTransforming Growth Factor beta1AnimalsCell DifferentiationCulture Media, ConditionedDisease Models, AnimalFemaleMiceSignal TransductionTooth RootCulture Media, ConditionedTransforming Growth Factor beta1

Identifiers

PMID37599332
PMCPMC10440342

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.