ArticleThe Journal of veterinary medical science2023
Sodium bicarbonate and salbutamol facilitate recovery from hyperkalemia-induced electrocardiogram abnormalities in bullfrog hearts.
Article in The Journal of veterinary medical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 3 citations in OpenAlex.
- Bullfrog heart model reproducing electrocardiographic changes of lateral wall myocardial infarction.The Journal of veterinary medical science · 2026Article
- Treatment of Hyperkalemia-Induced-Cardiac-Arrest by Dynamic Electrocardiogram and Point-of-Care-testing Potassium: A Case Report.Clinical medicine insights. Case reports · 2026Article
- Hydrogen peroxide exposure to bullfrog heart causes ST segment elevation.The Journal of veterinary medical science · 2025Article
- Pathological and functional significance of aging mouse kidneys: clinical implications to reduce the risk of hyper- or hypokalemia in the elderly.Kidney research and clinical practice · 2024Article
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4 authors at 1 institution in 1 country.
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Abstract
Hyperkalemia is a common electrolyte abnormality frequently complicated with chronic kidney disease. By injecting potassium chloride (KCl) solutions intravenously into bullfrogs, we reproduced typical electrocardiogram (ECG) abnormalities of hyperkalemia in the frog hearts, such as the peaked T waves and the widening of QRS complexes. Simultaneous recordings of cardiac action potentials showed morphological changes that synchronized with those of ECG. After 100 mM KCl injection, the widened QRS complexes continued for a while and gradually restored to their baseline widths. However, pre-treatment with sodium bicarbonate or salbutamol, which directly or indirectly stimulates Na
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