ArticleCortex; a journal devoted to the study of the nervous system and behavior2023
Mechanisms and neuroanatomy of response selection in tool and non-tool action tasks: Evidence from left-hemisphere stroke.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Causal dependencies between frontal and temporal lobe regions underlying word search and retrieval.bioRxiv : the preprint server for biology · 2026Article
- Visual processing of manipulable objects in the ventral stream is modulated by parietal action systems.Brain communications · 2026Article
- Competition between Tool and Hand Motion Impairs Movement Planning in Limb Apraxia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Object-directed action representations are componentially built in parietal cortex.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Causal Lesion Evidence for Two Motor Speech Coordination Networks in the Brain.bioRxiv : the preprint server for biology · 2025Article
- Left-hemisphere glioma drives systematic patterns of contralesional functional connectivity.Brain communications · 2025Article
- The "What" and "How" of Pantomime Actions.Vision (Basel, Switzerland) · 2024Review
- An Agent-Based Model to Reproduce the Boolean Logic Behaviour of Neuronal Self-Organised Communities through Pulse Delay Modulation and Generation of Logic Gates.Biomimetics (Basel, Switzerland) · 2024Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The ability to select between potential actions is central to the complex process of tool use. After left hemisphere stroke, individuals with limb apraxia make more hand action errors when gesturing the use of tools with conflicting hand actions for grasping-to-move and use (e.g., screwdriver) relative to tools that are grasped-to-move and used with the same hand action (e.g., hammer). Prior research indicates that this grasp-use interference effect is driven by abnormalities in the competitive action selection process. The goal of this project was to determine whether common mechanisms and neural substrates support the competitive selection of task-appropriate responses in both tool and non-tool domains. If so, the grasp-use interference effect in a tool use gesturing task should be correlated with response interference effects in the classic Eriksen flanker and Simon tasks, and at least partly overlapping neural regions should subserve the 3 tasks. Sixty-four left hemisphere stroke survivors (33 with apraxia) participated in the tool- and non-tool interference tasks and underwent T1 anatomical MRI. There were robust grasp-use interference effects (grasp-use conflict test) and response interference effects (Eriksen flanker and Simon tasks), but these effects were not correlated. Lesion-symptom mapping analyses showed that lesions to the left inferior parietal lobule, ventral premotor cortex, and insula were associated with grasp-use interference. Lesions to the left inferior parietal lobule, postcentral gyrus, insula, caudate, and putamen were associated with response interference in the Eriksen flanker task. Lesions to the left caudate and putamen were also associated with response interference in the Simon task. Our results suggest that the selection of hand posture for tool use is mediated by distinct cognitive mechanisms and partly distinct neuroanatomic substrates from those mapping a stimulus to an appropriate motor response in non-tool domains.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.