Evidence map›Paper›PMID 37598252›Full record

ArticleScientific reports2023

Endothelial CD34 expression and regulation of immune cell response in-vitro.

Lousineh Arakelian, Julien Lion, Guillaume Churlaud, Rezlene Bargui, Briac Thierry, Evelyne Mutabazi, Patrick Bruneval, Antonio José Alberdi, Christelle Doliger, Maëva Veyssiere and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

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  18. The Relevance of the Endothelium in Cardiopulmonary Disorders.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Lousineh Arakelian *Human Immunology, Pathophysiology, Immunotherapy, Inserm UMR 976, Paris, France. lousineh.arakelian@aphp.fr.
Julien Lion *Human Immunology, Pathophysiology, Immunotherapy, Inserm UMR 976, Paris, France.
Guillaume ChurlaudAP-HP, Hôpital Saint-Louis, Centre MEARY de Thérapie Cellulaire et Génique, 75010, Paris, France.
Rezlene BarguiHuman Immunology, Pathophysiology, Immunotherapy, Inserm UMR 976, Paris, France.
Briac ThierryHuman Immunology, Pathophysiology, Immunotherapy, Inserm UMR 976, Paris, France.
Evelyne MutabaziHuman Immunology, Pathophysiology, Immunotherapy, Inserm UMR 976, Paris, France.
Patrick BrunevalService de Cardiologie, Hôpital Européen Georges Pompidou, 75015, Paris, France.
Antonio José AlberdiUMS Saint-Louis US53/UAR2030, Université Paris Cité - INSERM - CNRS, Institut de Recherche Saint Louis, Paris, France.
Christelle DoligerUMS Saint-Louis US53/UAR2030, Université Paris Cité - INSERM - CNRS, Institut de Recherche Saint Louis, Paris, France.
Maëva VeyssiereHuman Immunology, Pathophysiology, Immunotherapy, Inserm UMR 976, Paris, France.
Jérôme Larghero *Human Immunology, Pathophysiology, Immunotherapy, Inserm UMR 976, Paris, France.
Nuala Mooney *Human Immunology, Pathophysiology, Immunotherapy, Inserm UMR 976, Paris, France.
Inserm · FRCentre National de la Recherche Scientifique · FRAssistance Publique – Hôpitaux de Paris · FRHôpital Européen Georges-Pompidou · FRHôpital Necker-Enfants Malades · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endothelial cells cover the lining of different blood vessels and lymph nodes, and have major functions including the transport of blood, vessel homeostasis, inflammatory responses, control of transendothelial migration of circulating cells into the tissues, and formation of new blood vessels. Therefore, understanding these cells is of major interest. The morphological features, phenotype and function of endothelial cells varies according to the vascular bed examined. The sialomucin, CD34, is widely used as an endothelial marker. However, CD34 is differentially expressed on endothelial cells in different organs and in pathological conditions. Little is known about regulation of endothelial CD34 expression or function. Expression of CD34 is also strongly regulated in-vitro in endothelial cell models, including human umbilical vein endothelial cells (HUVEC) and endothelial colony forming cells (ECFC). We have therefore analysed the expression and function of CD34 by comparing CD34

Indexed as

Angiopoietin-2Interleukin-33Antigens, CD34Cell Adhesion MoleculesHumansHuman Umbilical Vein Endothelial CellsLeukocytes, MononuclearAngiopoietin-2Antigens, CD34Cell Adhesion MoleculesInterleukin-33

Identifiers

PMID37598252
PMCPMC10439936
OpenAlexW4385999133

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.