Evidence map›Paper›PMID 37598229›Full record

ArticleScientific reports2023

Pontomedullary junction as a reference for spinal cord cross-sectional area: validation across neck positions.

Sandrine Bédard, Maxime Bouthillier, Julien Cohen-Adad

Abstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Spinal nerves as landmarks for spinal cord segment delineation: cervical cross-sectional area measurement in healthy subjects.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Rootlets-based registration to the PAM50 spinal cord template.Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
  7. Reproducible Spinal Cord Quantitative MRI Analysis with the Spinal Cord Toolbox.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024
    Review
  8. Automatic segmentation of the spinal cord nerve rootlets.Imaging neuroscience (Cambridge, Mass.) · 2024
    Article
  9. Review
  10. A simplified approach to define cervical vertebral levels in spinal cord MRI studies.Journal of neuroimaging : official journal of the American Society of Neuroimaging
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sandrine BédardNeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada. sandrine.bedard@polymtl.ca.
Maxime BouthillierCentre Hospitalier de l'Université de Montréal, University of Montreal, Montreal, QC, Canada.
Julien Cohen-AdadNeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada.

Funding

Canadian Institute of Health Research FDN-143263
6 · The paper itself

Abstract

Spinal cord cross-sectional area (CSA) is an important MRI biomarker to assess spinal cord atrophy in various neurodegenerative and traumatic spinal cord diseases. However, the conventional method of computing CSA based on vertebral levels is inherently flawed, as the prediction of spinal levels from vertebral levels lacks reliability, leading to considerable variability in CSA measurements. Computing CSA from an intrinsic neuroanatomical reference, the pontomedullary junction (PMJ), has been proposed in previous work to overcome limitations associated with using a vertebral reference. However, the validation of this alternative approach, along with its variability across and within participants under variable neck extensions, remains unexplored. The goal of this study was to determine if the variability of CSA across neck flexions/extensions is reduced when using the PMJ, compared to vertebral levels. Ten participants underwent a 3T MRI T2w isotropic scan at 0.6 mm

Indexed as

Cone-Rod DystrophiesSpinal Cord DiseasesSpinal Cord InjuriesSpondylosisHumansReproducibility of ResultsSpine

Identifiers

PMID37598229
PMCPMC10439961

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.