Evidence map›Paper›PMID 37597697›Full record

ArticleBioorganic & medicinal chemistry letters2023

Discovery of 5-sulfonyltetrazoles as neuroblastoma differentiation agents.

Andrew C Johns, Alejandro Oviedo, Zhenze Zhao, Liqin Du, Alexander Kornienko

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Andrew C JohnsDepartment of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA.
Alejandro OviedoDepartment of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA.
Zhenze ZhaoDepartment of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA.
Liqin DuDepartment of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA. Electronic address: liqindu6@txstate.edu.
Alexander KornienkoDepartment of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA. Electronic address: a_k76@txstate.edu.
Texas State University · US

Funding

South Texas Doctoral Bridge ProgramR25GM102783 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI OYAJOBI, BABATUNDE OLUKAYODE, WHITTEN, STEVEN T · 2013 to 2022
$3.1M
Acid-Sensitive Glioblastoma Prodrugs Derived from Ophiobolin AR15CA227680 · NCI · TEXAS STATE UNIVERSITY · PI KORNIENKO, ALEXANDER · 2019 to 2019
$462k
Discovery of New Differentiation Agents for Neuroblastoma TherapyR15CA213199 · NCI · TEXAS STATE UNIVERSITY · PI DU, LIQIN · 2017 to 2017
$462k
NCI NIH HHS R15 CA213199NCI NIH HHS R15 CA227680NIGMS NIH HHS R25 GM102783
6 · The paper itself

Abstract

Previously, we developed an innovative high-content screening (HCS) approach to quantify neuroblastoma cell differentiation based on neurite outgrowth, a morphological differentiation marker of neuroblastoma cells. Here, we report the utilization of this platform to identify 1-methyl-5-(ethylsulfonyl)-1H-tetrazole (3a) as a new neuroblastoma differentiation agent using the ChemBridge Diverset

Indexed as

Antineoplastic AgentsNeuroblastomaCell DifferentiationGene LibraryHumansNeuronal OutgrowthAntineoplastic AgentsDifferentiationHeterocycleHigh throughput screeningLibraryNeuroblastoma

Identifiers

PMID37597697
PMCPMC10860674
OpenAlexW4385988669

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.