Evidence map›Paper›PMID 37597170›Full record

ArticleThe Laryngoscope2024

Cell-Based Outer Vocal Fold Replacement Both Treats and Prevents Vocal Fold Scarring in Rabbits.

Rodell Santuray, Patrick Schlegel, Zhaoyan Zhang, Neha Reddy, Yazeed Alhiyari, Jennifer L Long

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Laryngoscope, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. A Novel Imaging Technique to Identify Vocal Fold Scar Formation.Laryngoscope investigative otolaryngology · 2026
    Article
  4. Article
  5. Vocal Fold Injury Produces Similar Biomechanical Outcomes in Male and Female Rabbits.Journal of voice : official journal of the Voice Foundation · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Rodell SanturayDepartment of Head and Neck Surgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, U.S.A.ORCID 0000-0002-0129-1255
Patrick SchlegelDepartment of Head and Neck Surgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, U.S.A.
Zhaoyan ZhangDepartment of Head and Neck Surgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, U.S.A.ORCID 0000-0002-2379-6086
Neha ReddyDepartment of Head and Neck Surgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, U.S.A.ORCID 0000-0003-3707-0531
Yazeed AlhiyariDepartment of Head and Neck Surgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, U.S.A.
Jennifer L LongDepartment of Head and Neck Surgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, U.S.A.ORCID 0000-0002-4185-2328
University of California, Los Angeles · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Tissue engineering to regenerate functional vocal fold after scarring or tissue lossR01DC016959 · NIDCD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LONG, JENNIFER L · 2018 to 2022
$3.7M
Long-term function of vocal fold replacement in swineI01RX003649 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI Jennifer L Long · 2023 to 2026
–
NCATS NIH HHS UL1 TR001881NIDCD NIH HHS R01 DC016959NIH HHS NIDCD R01 DC016959RRD VA I01 RX003649
6 · The paper itself

Abstract

objectiveNumerous pharmacological and cell-based treatments have shown promise in preventing vocal fold (VF) scarring when applied at the time of injury. A common clinical scenario, however, is the finding of mature scar impeding voicing. Many treatments are less effective in remodeling existing scar tissue. This objective of this study is to determine if a cell-based outer vocal fold replacement (COVR) effectively restores VF function when applied to existing scar.

methodsEighteen rabbits were allocated to three groups: unilateral COVR implant at the time of cordectomy (acute COVR); unilateral cordectomy followed by COVR implant 2 months later (chronic COVR); and unilateral cordectomy followed by sham implant surgery 2 months later (chronic scar). Larynges were harvested 2 months after implant or sham surgery.

resultsAll larynges in the COVR groups demonstrated human leukocyte antigen labeling on immunohistochemistry (IHC). COVR groups had increased hyaluronic acid content compared with normal. VF stiffness as measured by elastic moduli in acute COVR and chronic COVR were similar to their contralateral unoperated VF.

conclusionCOVR implantation in both acutely injured and chronically scarred VF demonstrate persistence of implanted cells, restored tissue biomechanics, and increased hyaluronic acid content. LEVEL OF EVIDENCE: NA Laryngoscope, 134:764-772, 2024.

Indexed as

CicatrixVocal CordsAnimalsHumansHyaluronic AcidRabbitsHyaluronic Acidadipose-derived stromal cellschronic scarexcised phonationextracellular matrixfibrinregenerative medicinevocal fold

Identifiers

PMID37597170
PMCPMC10842642
OpenAlexW4386002196

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.