Evidence map›Paper›PMID 37597167›Full record

ArticleThe Laryngoscope2024

Bilateral Functional Electrical Stimulation for the Treatment of Presbyphonia in a Sheep Model.

Andrijana Kirsch, Claus Gerstenberger, Bernhard Jakubaß, Magdalena Tschernitz, Justin D Perkins, Andrea Groselj-Strele, Hermann Lanmüller, Jonathan C Jarvis, Stefan Kniesburges, Michael Döllinger and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Laryngoscope, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. An Epidemiological Analysis of Vocal Fold Atrophy at the Tokyo Voice Center.International archives of otorhinolaryngology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Andrijana KirschDivision of Phoniatrics, ENT University Hospital, Medical University of Graz, Graz, Austria.ORCID 0000-0002-6623-0234
Claus GerstenbergerDivision of Phoniatrics, ENT University Hospital, Medical University of Graz, Graz, Austria.
Bernhard JakubaßDivision of Phoniatrics and Pediatric Audiology at the Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Magdalena TschernitzDivision of Phoniatrics, ENT University Hospital, Medical University of Graz, Graz, Austria.
Justin D PerkinsClinical Science and Services, Royal Veterinary College, Hatfield, UK.
Andrea Groselj-StreleCore Facility Computational Bioanalytics, Center for Medical Research, Medical University of Graz, Graz, Austria.
Hermann LanmüllerCenter of Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
Jonathan C JarvisSchool of Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.
Stefan KniesburgesDivision of Phoniatrics and Pediatric Audiology at the Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0002-4902-0534
Michael DöllingerDivision of Phoniatrics and Pediatric Audiology at the Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Markus GugatschkaDivision of Phoniatrics, ENT University Hospital, Medical University of Graz, Graz, Austria.ORCID 0000-0001-8091-8812
Medical University of Graz · ATFriedrich-Alexander-Universität Erlangen-Nürnberg · DELiverpool John Moores University · GBMedical University of Vienna · ATRoyal Veterinary College · GB

Funding

Austrian Science Fund I 3997Deutsche Forschungsgemeinschaft DO1247/12-1
6 · The paper itself

Abstract

objectivesThe aim of the study was to increase muscle volume and improve phonation characteristics of the aged ovine larynx by functional electrical stimulation (FES) using a minimally invasive surgical procedure.

methodsStimulation electrodes were placed bilaterally near the terminal adduction branch of the recurrent laryngeal nerves (RLN). The electrodes were connected to battery powered pulse generators implanted subcutaneously at the neck region. Training patterns were programmed by an external programmer using a bidirectional radio frequency link. Training sessions were repeated automatically by the implant every other day for 1 week followed by every day for 8 weeks in the awake animal. Another group of animals were used as sham, with electrodes positioned but not connected to an implant. Outcome parameters included gene expression analysis, histological assessment of muscle fiber size, functional analysis, and volumetric measurements based on three-dimensional reconstructions of the entire thyroarytenoid muscle (TAM).

resultsIncrease in minimal muscle fiber diameter and an improvement in vocal efficiency were observed following FES, compared with sham animals.

conclusionThis is the first study to demonstrate beneficial effects in the TAM of FES at molecular, histological, and functional levels. FES of the terminal branches of the RLN reversed the effects of age-related changes and improved vocal efficiency. LEVEL OF EVIDENCE: NA Laryngoscope, 134:848-854, 2024.

Indexed as

Electric Stimulation TherapyVocal Cord ParalysisAnimalsDisease Models, AnimalElectric StimulationLaryngeal MusclesSheepaged larynxfunctional electrical stimulationvocal fold atrophy

Identifiers

PMID37597167
PMCPMC10952233
OpenAlexW4386009535

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.