Evidence map›Paper›PMID 37597095›Full record

ArticleEndocrine2024

Site specific differences in vBMD and geometry in postmenopausal women with primary hyperparathyroidism.

E Karlafti, I Dontas, I Lambrinoudaki, I Vlamis, K Lampropoulou-Adamidou, K Makris, I Trifonidi, A Galanos, G Trovas, E Chronopoulos and 1 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Endocrine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05426512 (Effect of Mechanical Loading on vBMD and Geometry in Patients With Primary Hyperparathyroidism), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05426512 completednot on this map

Effect of Mechanical Loading on vBMD and Geometry in Patients With Primary Hyperparathyroidism

TypeobservationalSponsorEFSTATHIOS CHRONOPOULOSRan2016 to 2020Enrolled120ConditionsPrimary Hyperparathyroidism
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Bone Disease in Primary Hyperparathyroidism.Journal of musculoskeletal & neuronal interactions · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

E KarlaftiLaboratory for Research of the Musculoskeletal System "Th. Garofalidis", Medical School, National and Kapodistrian University of Athens, KAT General Hospital, Kifissia, Athens, Greece.
I DontasLaboratory for Research of the Musculoskeletal System "Th. Garofalidis", Medical School, National and Kapodistrian University of Athens, KAT General Hospital, Kifissia, Athens, Greece.ORCID 0000-0002-2440-0119
I LambrinoudakiMenopause Unit, Second Department of Obstetrics and Gynecology, Aretaieio Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.ORCID 0000-0003-1488-2668
I Vlamis3rd Department of Orthopaedics, Medical School, National and Kapodistrian University of Athens, KAT General Hospital, Kifissia, Athens, Greece.
K Lampropoulou-AdamidouLaboratory for Research of the Musculoskeletal System "Th. Garofalidis", Medical School, National and Kapodistrian University of Athens, KAT General Hospital, Kifissia, Athens, Greece.ORCID 0000-0003-3434-6053
K MakrisClinical Biochemistry Department, KAT General Hospital, Kifissia, Athens, Greece.ORCID 0000-0002-7896-9028
I TrifonidiClinical Biochemistry Department, KAT General Hospital, Kifissia, Athens, Greece.ORCID 0000-0002-3999-8459
A GalanosLaboratory for Research of the Musculoskeletal System "Th. Garofalidis", Medical School, National and Kapodistrian University of Athens, KAT General Hospital, Kifissia, Athens, Greece.ORCID 0000-0001-8913-9938
G TrovasLaboratory for Research of the Musculoskeletal System "Th. Garofalidis", Medical School, National and Kapodistrian University of Athens, KAT General Hospital, Kifissia, Athens, Greece.ORCID 0000-0002-6702-650X
E Chronopoulos *Laboratory for Research of the Musculoskeletal System "Th. Garofalidis", Medical School, National and Kapodistrian University of Athens, KAT General Hospital, Kifissia, Athens, Greece.ORCID 0000-0003-1667-9292
S Tournis *Laboratory for Research of the Musculoskeletal System "Th. Garofalidis", Medical School, National and Kapodistrian University of Athens, KAT General Hospital, Kifissia, Athens, Greece. stournis@med.uoa.gr.ORCID 0000-0002-8301-324X
National and Kapodistrian University of Athens · GRKAT General Hospital of Attica · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePrimary Hyperparathyroidism (PHPT) is associated with catabolic effects at both trabecular and cortical bone. Mechanical loading is one of the most important natural anabolic stimuli for bone at all ages. The present study was designed to assess the impact of PHPT on vBMD and bone geometry using peripheral quantitative computed tomography (pQCT) at the radius and tibia, sites with similar structural characteristics, but subject to different loading conditions.

methodsWe evaluated the impact of PHPT on bone, by comparing the z-scores of volumetric Bone Mineral Density (vBMD) and indices of bone geometry simultaneously at the tibia and the radius by pQCT, skeletal sites with similar structure, but subject to different loading conditions. Forty-one postmenopausal women with PHPT and 79 controls, comprised the study group.

resultsAt both trabecular and cortical sites, vBMD and bone geometry indices were significantly lower in patients compared with controls. In patients with PHPT, apart from a lower z-score for total vBMD (p = 0.01) at the radius, there was no other difference between the radius and the tibia at the trabecular sites. On the contrary, at cortical sites, the z-scores of cortical bone mineral content (p = 0.02), cortical vBMD (p = 0.01) and cortical cross-sectional area (p = 0.05) were significantly lower at the radius compared with the tibia, indicating that cortical bone at the weight bearing tibia might be less affected by the catabolic actions of continuous parathyroid hormone (PTH) exposure. PTH levels were positively associated with the difference in z-scores of cort BMD (r = 0.439, p < 0.01) indicating that in more severe cases, as expressed by higher PTH levels, the deleterious effects at the non-weight bearing radius might be accentuated.

conclusionWe found that in postmenopausal women with PHPT, both trabecular and cortical bone are adversely affected. However, at the weight bearing tibia as compared with the radius, the deleterious effects, especially on cortical bone, seem to be attenuated. TRIAL REGISTRATION NUMBER: NCT05426512, 21/06/2022, "retrospectively registered".

Indexed as

Bone DensityHyperparathyroidism, PrimaryAbsorptiometry, PhotonBone and BonesFemaleHumansParathyroid HormonePostmenopauseRadiusParathyroid HormoneMechanical loadingPeripheral quantitative computed tomographyPrimary hyperparathyroidismVolumetric bone mineral density

Identifiers

PMID37597095
OpenAlexW4386001112

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.