ArticlePlant biotechnology journal2024
A fungal CFEM-containing effector targets NPR1 regulator NIMIN2 to suppress plant immunity.
Article in Plant biotechnology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 52 citations in OpenAlex.
- Infection mechanisms ofiMeta · 2026Article
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- Systematic Identification and Functional Characterisation of Colletotrichum fructicola Effectors During Camellia oleifera Colonisation.Molecular plant pathology · 2026Article
- Molecular insights and integrated management of Glomerella leaf spot in apple.Horticulture research · 2026Review
- A neprilysin effector from the pinewood nematode Bursaphelenchus xylophilus targets pine caffeic acid O-methyltransferase and inhibits lignin biosynthesis.Pest management science · 2026Article
- Biological Control ofMicroorganisms · 2026Article
- GhPsbO breaks the growth-immunity tradeoff by simultaneously promoting growth and defense in cotton.The Plant cell · 2026Article
- AhNPR4B Interacts with AhPR2-Like and May Contribute to Disease Resistance and Cold Tolerance in Peanut.Plants (Basel, Switzerland) · 2026Article
- Comprehensive pan-effectome investigation reveals central effector genes in woody plant pathogen Botryosphaeriaceae.Applied and environmental microbiology · 2026Article
- CgCFEM1 and CgCFEM2 modulate virulence in Colletotrichum gloeosporioides by integrated regulation of TOR and cAMP-PKA signaling pathways.BMC microbiology · 2026Article
- Elucidation of the Biological Function and Early-Infection Cell Cycle Regulatory Mechanism of Avocado-InfectingFoods (Basel, Switzerland) · 2026Article
- Jasmonate Modulates Strawberry Susceptibility to Anthracnose by Activating SnRK2.1 to Regulate the WRKY50-JAZ5 Module.Plant biotechnology journal · 2026Article
- Genome-Wide Identification of CFEM Proteins inPlants (Basel, Switzerland) · 2026Article
- Functional characterization of a CFEM domain-containing protein in the mycoparasitic fungus Clonostachys rosea reveals antimicrobial activity and a role in conidiation.Molecular genetics and genomics : MGG · 2026Article
- ApCtf1β-Interacting Target Proteins BDPH1 and BDEUL12 Regulate Pathogenicity in Arthrinium phaeospermum.Molecular plant pathology · 2026Article
- Genomic analysis ofMycoscience · 2026Article
- CFEM proteins: unique to fungi with essential roles in plant host interactions.Frontiers in fungal biology · 2026Review
- Mechanisms of altitude-driven mycotoxin variation in stored wheat: a metabolomic and transcriptomic approach.BMC microbiology · 2025Article
- Article
- AScience advances · 2025Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Colletotrichum fructicola causes a broad range of plant diseases worldwide and secretes many candidate proteinous effectors during infection, but it remains largely unknown regarding their effects in conquering plant immunity. Here, we characterized a novel effector CfEC12 that is required for the virulence of C. fructicola. CfEC12 contains a CFEM domain and is highly expressed during the early stage of host infection. Overexpression of CfEC12 suppressed BAX-triggered cell death, callose deposition and ROS burst in Nicotiana benthamiana. CfEC12 interacted with apple MdNIMIN2, a NIM1-interacting (NIMIN) protein that putatively modulates NPR1 activity in response to SA signal. Transient expression and transgenic analyses showed that MdNIMIN2 was required for apple resistance to C. fructicola infection and rescued the defence reduction in NbNIMIN2-silenced N. benthamiana, supporting a positive role in plant immunity. CfEC12 and MdNPR1 interacted with a common region of MdNIMIN2, indicating that CfEC12 suppresses the interaction between MdNIMIN2 and MdNPR1 by competitive target binding. In sum, we identified a fungal effector that targets the plant salicylic acid defence pathway to promote fungal infection.
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