Evidence map›Paper›PMID 37596834›Full record

ArticleEpilepsia2023

Seizure control in women with epilepsy undergoing assisted reproductive technology.

Aisha A Abdulrazaq, Alessandra J Ainsworth, Jeffrey W Britton, Chandra C Shenoy, Samir N Babayev, Gregory D Cascino, Kelsey M Smith

Abstract read
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In one paragraph

Article in Epilepsia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Aisha A AbdulrazaqDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0009-0007-6051-4766
Alessandra J AinsworthDepartment of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota, USA.
Jeffrey W BrittonDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Chandra C ShenoyDepartment of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota, USA.
Samir N BabayevDepartment of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota, USA.
Gregory D CascinoDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Kelsey M SmithDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0001-8659-3801
Mayo Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study was to determine seizure control in women with epilepsy (WWE) undergoing assisted reproductive technology (ART). Through retrospective chart review, WWE undergoing ART were identified. Demographics and details regarding epilepsy type, seizure control, and ART procedures were extracted. Seizure frequency prior to and during ART were compared. We identified 12 WWE, who underwent 29 embryo transfers, resulting in 16 pregnancies and 10 live births. Nine women were seizure-free at least 2 years before fertility treatment, including three with resolved epilepsy. Seven were on antiseizure medications throughout fertility treatment and pregnancy, with only one on polytherapy. Eleven (all with controlled epilepsy or epilepsy in remission) remained seizure-free throughout fertility treatment. One woman with drug-resistant epilepsy continued to have seizures throughout fertility treatment and pregnancy without an exacerbation of seizure frequency. There was no increased seizure frequency associated with fertility treatment and subsequent pregnancy in this small series of WWE. Although this study was statistically underpowered, our results provide some preliminary evidence that ART might not pose a threat to seizure control, but larger, confirmatory studies are necessary.

Indexed as

EpilepsyReproductive Techniques, AssistedSeizuresAdultAnticonvulsantsEmbryo TransferFemaleHumansPregnancyPregnancy ComplicationsRetrospective StudiesYoung AdultAnticonvulsantsantiseizure medicationsassisted reproductive technologyin vitro fertilizationwomen with epilepsy

Identifiers

PMID37596834
OpenAlexW4385997360

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.