Evidence map›Paper›PMID 37596720›Full record

ArticleJournal of neurochemistry2024

Ketamine improves neuronal recovery following spreading depolarization in peri-infarct tissues.

Katelyn M Reinhart, Russell A Morton, K C Brennan, Andrew P Carlson, C William Shuttleworth

Open access · greenAbstract read
In one paragraph

Article in Journal of neurochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  3. Review
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  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Anesthetics in pathological cerebrovascular conditions.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025
    Review
  11. Article
  12. Article
  13. Synaptic ZnNeurobiology of disease · 2024
    Article
  14. Synaptic ZnbioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Katelyn M ReinhartDepartment of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
Russell A MortonDepartment of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
K C BrennanDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Andrew P CarlsonDepartment of Neurosurgery, University of New Mexico, Albuquerque, New Mexico, USA.ORCID 0000-0003-2189-3699
C William ShuttleworthDepartment of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.ORCID 0000-0002-0237-4888
University of New Mexico · USUniversity of Utah · US

Funding

University of New Mexico (UNM) Center for Brain Recovery and RepairP20GM109089 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI SHUTTLEWORTH, CLAUDE W · 2015 to 2024
$22.7M
MINORITY INSTITUTIONAL RESEARCH TRAINING PROGRAM (T32)T32HL007736 · NHLBI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI RESTA, THOMAS C · 1993 to 2025
$6.5M
Astrocytic mechanisms in a new genetic model of migraineR01NS104742 · NINDS · UNIVERSITY OF UTAH · PI BRENNAN, KEVIN CHRISTOPHER · 2018 to 2022
$2.5M
Spreading Depolarizations and Neuronal VulnerabilityR01NS106901 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Claude W Shuttleworth · 2018 to 2026
$2.5M
Training in the Development of Novel Interventions for the Treatment of Neurological and Neurobehavioral DisordersT32NS115723 · NINDS · UNIVERSITY OF UTAH · PI KEEFE, KRISTEN A · 2020 to 2024
$1.1M
NHLBI NIH HHS T32 HL007736NIGMS NIH HHS 109089NIGMS NIH HHS P20 GM109089NINDS NIH HHS NS104724NINDS NIH HHS NS106901NINDS NIH HHS R01 NS104742NINDS NIH HHS R01 NS106901NINDS NIH HHS T32 NS115723U.S. Department of Defense PR 200891
6 · The paper itself

Abstract

Spreading depolarization (SD) has emerged as an important contributor to the enlargement of acute brain injuries. We previously showed that the N-methyl-D-aspartate receptor antagonist ketamine was able to prevent deleterious consequences of SD in brain slices, under conditions of metabolic compromise. The current study aimed to extend these observations into an in vivo stroke model, to test whether gradients of metabolic capacity lead to differential accumulation of calcium (Ca

Indexed as

Cortical Spreading DepressionKetamineMice, Inbred C57BLAnimalsCalciumExcitatory Amino Acid AntagonistsInfarction, Middle Cerebral ArteryMaleMiceNeuronsRecovery of FunctionCalciumExcitatory Amino Acid AntagonistsKetaminecalciumexcitotoxicityNMDA receptorspreading depressionstroke

Identifiers

PMID37596720
PMCPMC10986311
OpenAlexW4385997270

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.