ArticleEndocrine2024
Lateral lymph node metastasis in papillary thyroid microcarcinoma: a study of 5241 follow-up patients.
Article in Endocrine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Radiomics-based prediction model for lymph node metastasis in thyroid microcarcinoma.BMC surgery · 2026Article
- Predictive significance of anterior and posterior minimal extrathyroidal extension for central lymph node metastasis in cN0 papillary thyroid carcinoma.Clinical & experimental metastasis · 2026Article
- Decision-making value of a 1-cm tumor diameter cut-off for postoperativeAmerican journal of translational research · 2026Article
- Nomogram prediction for central lymph node metastasis in papillary thyroid microcarcinoma of the isthmus based on clinical and ultrasound features.Frontiers in surgery · 2026Article
- Risk Stratification in Papillary Thyroid Microcarcinoma: Clinical Features Predicting Multifocality, Lymph Node Metastasis, and Recurrence - A Retrospective Cohort Study.Cancer management and research · 2026Article
- Evaluation of relevant indicators in the diagnosis of cervical lymph node metastasis in papillary thyroid cancer.Frontiers in oncology · 2026Article
- Dose-Response Relationship Between BRAF V600E Abundance and Cervical Lymph Node Metastasis in Papillary Thyroid Cancer.Cancers · 2025Article
- Predictive Factors of Lymph Node Metastasis in Papillary Thyroid Microcarcinoma (PTMC).Medicina (Kaunas, Lithuania) · 2025Article
- Evaluation of predictive factors for lymph node metastasis in thyroid microcarcinoma: a two-year experience from two high-volume centers.Updates in surgery · 2025Article
- Analysis of Risk Factors for High-Risk Lymph Node Metastasis in Papillary Thyroid Microcarcinoma.Cancers · 2025Article
- Explainable multimodal deep learning for predicting thyroid cancer lateral lymph node metastasis using ultrasound imaging.Nature communications · 2025Article
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- Proteomic Analysis of Tissue Proteins Related to Lateral Lymph Node Metastasis in Papillary Thyroid Microcarcinoma.Journal of proteome research · 2025Article
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- Serum small extracellular vesicles-derived BST2 as a biomarker for papillary thyroid microcarcinoma promotes lymph node metastasis.Cancer gene therapy · 2025Article
- Risk factors for cervical lymph node metastasis at different lateral levels in papillary thyroid cancer: level III as the central hub.Gland surgery · 2024Article
- Clinicopathological Features and Molecular Signatures of Lateral Neck Lymph Node Metastasis in Papillary Thyroid Microcarcinoma.Endocrinology and metabolism (Seoul, Korea) · 2024Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo investigate the impact of lateral lymph node metastasis in papillary thyroid microcarcinoma (PTMC).
methods5241 PTMC patients with follow-up information were enrolled in the current study. These patients underwent primary surgery in our situation from January 1997 to December 2016. Additionally, a validation cohort consisting of 274 PTMC patients who underwent primary surgery between January 2020 and December 2021 was also included. Univariable and multivariate logistic analyses were conducted to identify the association between clinicopathologic features and lateral lymph node metastasis (LLNM). Kaplan-Meier survival curve analysis was used to calculate the disease-free survival (DFS) rate. The fitting curve was generated to identify the quantitative relationship between central lymph node metastases (CLNM) and LLNM.
resultsOf 5241 PTMC patients, cervical lymph node metastasis was detected in 1494 (28.5%) cases, including 1364 (26.0%) with CLNM only and 130 (2.5%) with LLNM. With a median follow-up time of 60 months (interquartile range [IQR], 44-81), recurrence was detected in 114 patients (2.2%). Multivariate Cox regression analyses showed that LNM was the only independent risk factor for recurrence, with HR values of 3.03 in CLNM and 11.14 in LLNM, respectively. Tumor diameter >0.5 cm (hazard ratio [HR]:1.80), multifocality (HR:2.59), bilaterality (HR:2.13), extrathyroidal invasion (HR:2.13), and CLNM (HR:5.11) were independent risk factors for LLNM. The prevalence of LLNM escalated significantly with increasing number of lymph node involvement in CLNM when stratified by the number of metastatic lymph nodes and trend was observed similarly in the validation cohort. The fitting curve showed that the incidence of LLNM could be as high as 20.7% when the number of CLNM ≥ 5.
conclusionsBy analyzing a large database with follow-up information, our study provides evidence that LLNM is significantly correlated with tumor recurrence in patients with PTMC. Tumor size (>0.5 cm), multifocality, bilaterality, extrathyroidal extension (ETE) and CLNM are independent risk factors for LLNM.
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