Evidence map›Paper›PMID 37596344›Full record

ArticleScientific reports2023

Genetic associations between alcohol phenotypes and life satisfaction: a genomic structural equation modelling approach.

Kaitlin E Bountress, Shannon E Cusack, Sage E Hawn, Andrew Grotzinger, Daniel Bustamante, Robert M Kirkpatrick, Howard J Edenberg, Ananda B Amstadter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kaitlin E BountressVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 E. Leigh St. Biotech One Suite 101, Richmond, VA, 23219, USA. kaitlin.bountress@vcuhealth.org.
Shannon E CusackVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 E. Leigh St. Biotech One Suite 101, Richmond, VA, 23219, USA.
Sage E HawnDepartment of Psychology, Old Dominion University, Norfolk, USA.
Andrew GrotzingerInstitute for Behavior Genetics, Behavioral, Psychiatric, and Statistical Genetics, University of Colorado Boulder, Boulder, USA.
Daniel BustamanteVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 E. Leigh St. Biotech One Suite 101, Richmond, VA, 23219, USA.
Robert M KirkpatrickVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 E. Leigh St. Biotech One Suite 101, Richmond, VA, 23219, USA.
Howard J EdenbergSchool of Medicine, Indiana University, Bloomington, IN, USA.
Ananda B AmstadterVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 E. Leigh St. Biotech One Suite 101, Richmond, VA, 23219, USA.

Funding

Research Training: Psychiatric &Statistical GeneticsT32MH020030 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI HERMINE H MAES, MICHAEL CHURTON NEALE · 1999 to 2026
$6.7M
Program Development and Pilot CoreP30AG066614 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI KAREN L FINGERMAN · 2020 to 2026
$5.2M
Dissecting the Multivariate Genetic Architecture of Psychiatric DiseasesR01MH120219 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI NIVARD, MICHEL GUILLAUME, TUCKER-DROB, ELLIOT MAX · 2020 to 2024
$3.3M
7/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109532 · NIMH · WASHINGTON UNIVERSITY · PI AGRAWAL, ARPANA, EDENBERG, HOWARD J · 2016 to 2020
$3.1M
Large-Scale Genomic Analysis of Aging-Related Cognitive Change Prior to Dementia OnsetRF1AG073593 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI TUCKER-DROB, ELLIOT MAX · 2021 to 2021
$2.1M
Alcohol Use Phenotypes and Posttraumatic Stress Disorder: Investigating Shared Genetic, Behavioral, and Psychophysiological Risk FactorsK01AA028058 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI BOUNTRESS, KAITLIN ELIZABETH · 2020 to 2024
$876k
NIAAA NIH HHS K01 AA028058NIA NIH HHS P30 AG066614NIA NIH HHS RF1 AG073593NIMH NIH HHS R01 MH120219NIMH NIH HHS T32 MH020030NIMH NIH HHS U01 MH109532
6 · The paper itself

Abstract

Alcohol use (i.e., quantity, frequency) and alcohol use disorder (AUD) are common, associated with adverse outcomes, and genetically-influenced. Genome-wide association studies (GWAS) identified genetic loci associated with both. AUD is positively genetically associated with psychopathology, while alcohol use (e.g., drinks per week) is negatively associated or NS related to psychopathology. We wanted to test if these genetic associations extended to life satisfaction, as there is an interest in understanding the associations between psychopathology-related traits and constructs that are not just the absence of psychopathology, but positive outcomes (e.g., well-being variables). Thus, we used Genomic Structural Equation Modeling (gSEM) to analyze summary-level genomic data (i.e., effects of genetic variants on constructs of interest) from large-scale GWAS of European ancestry individuals. Results suggest that the best-fitting model is a Bifactor Model, in which unique alcohol use, unique AUD, and common alcohol factors are extracted. The genetic correlation (r

Indexed as

AlcoholismGenome-Wide Association StudyEthanolGenomicsHumansLatent Class AnalysisPhenotypeEthanol

Identifiers

PMID37596344
PMCPMC10439217

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.