ArticleNature communications2023
Engineered NIR-II fluorophores with ultralong-distance molecular packing for high-contrast deep lesion identification.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 107 citations in OpenAlex.
- Visual theranostic oral nanozymes for IBD from principles to preclinical design.Bioactive materials · 2026Review
- A NIR-II AIEgen with superior fluorescence and photothermal performance for precision theranostics.Science advances · 2026Article
- Functional matrix engineering enables aggregate-state photophysics in tumor-responsive organic NIR-II phototheranostics.Materials today. Bio · 2026Article
- Rare-Earth Nanomaterials for Advanced Theranostics of Atherosclerosis.Chemical & biomedical imaging · 2026Review
- Tailoring Photonic Landscape: Nanoengineering Empowers NIR-II Lanthanide Luminescence for Versatile Biomedical Applications.Small methods · 2026Review
- β‑Anomeric Mannopentaose-Based Nonenzymatic NIR Glucose Sensor Enabling Cost-Effective Continuous Monitoring.ACS measurement science au · 2026Article
- Dilating the aging clock with light.Innovation (Cambridge (Mass.)) · 2026Review
- Nitric Oxide Conjugation Transforms NIR-II AIEgens Into Potent Hypoxia-Tolerant Type I Photosensitizers.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Smart molecular design of NIR-II organic fluorophores through self-driven iterative evolution, deep learning, and fragment-based assembly.Smart molecules : open access · 2026Article
- Asymmetric Xanthene with Noncovalent Conformation Locks to Attain High Fluorescence >1500 nm.Journal of the American Chemical Society · 2026Article
- NIR Excitation in Atomically Precise Nanoclusters via Two-Photon and Three-Photon Absorption.Accounts of chemical research · 2026Article
- Real-Time and High-Resolution NIR-II-L Imaging of Netrin-1-Mediated Neurovascular Coupling Driven by Dose-Dependent Electroacupuncture.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Real-Time In Vivo Detection of Nanocarrier Number and Velocity in the Cerebrovasculature Using Hot Band Absorption.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Molecular mechanism of biocompatible clusteroluminogens from citric acid and l-lysine.RSC advances · 2026Article
- Ultrasensitive In Vivo Imaging of Adoptive Immune Cell Distribution and Expansion Using Second Near-Infrared Conjugated Oligoelectrolyte Probes.Research (Washington, D.C.) · 2026Article
- S···O Conformation Locks Synergistic Alkoxy Chain Engineering of NIR-II Phototheranostic Molecules for Precision Hepatocellular Carcinoma Theranostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Delineating precise surgical resection areas: recent advances in NIR-II fluorescence imaging molecular probes.Frontiers in oncology · 2026Review
- Rational design of ultrabright NIR-II nanofluorophores with enhanced photothermal conversion efficiency for targeted chemodynamic-hypothermal photothermal therapy of hepatocellular carcinoma.Materials today. Bio · 2025Article
- Treating venous malformations with nanomedicines.Nanomedicine (London, England) · 2025Review
- Boosting the brightness of aggregation-caused quenching chromophore-based covalent organic frameworks via energy level matching strategy.Nature communications · 2025Article
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The limited signal of long-wavelength near-infrared-II (NIR-II, 900-1880 nm) fluorophores and the strong background caused by the diffused photons make high-contrast fluorescence imaging in vivo with deep tissue disturbed still challenging. Here, we develop NIR-II fluorescent small molecules with aggregation-induced emission properties, high brightness, and maximal emission beyond 1200 nm by enhancing electron-donating ability and reducing the donor-acceptor (D-A) distance, to complement the scarce bright long-wavelength emissive organic dyes. The convincing single-crystal evidence of D-A-D molecular structure reveals the strong inhibition of the π-π stacking with ultralong molecular packing distance exceeding 8 Å. The delicately-designed nanofluorophores with bright fluorescent signals extending to 1900 nm match the background-suppressed imaging window, enabling the signal-to-background ratio of the tissue image to reach over 100 with the tissue thickness of ~4-6 mm. In addition, the intraluminal lesions with strong negatively stained can be identified with almost zero background. This method can provide new avenues for future long-wavelength NIR-II molecular design and biomedical imaging of deep and highly scattering tissues.
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