Evidence map›Paper›PMID 37596165›Full record

ArticleCancer epidemiology2024

Genetically inferred birthweight, height, and puberty timing and risk of osteosarcoma.

D Matthew Gianferante, Amy Moore, Logan G Spector, William Wheeler, Tianzhong Yang, Aubrey Hubbard, Richard Gorlick, Ana Patiño-Garcia, Fernando Lecanda, Adrienne M Flanagan and 22 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer epidemiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. SMARCAL1 is a new osteosarcoma predisposition gene.Journal of the National Cancer Institute · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 16 institutions in 7 countries.

D Matthew GianferanteDivision of Cancer Epidemiology and Genetics, NCI, NIH, Rockville, MD, USA.
Amy MooreDivision of Cancer Epidemiology and Genetics, NCI, NIH, Rockville, MD, USA.
Logan G SpectorDepartment of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA.
William WheelerInformation Management Services, Rockville, MD, USA.
Tianzhong YangDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Aubrey HubbardDivision of Cancer Epidemiology and Genetics, NCI, NIH, Rockville, MD, USA.
Richard GorlickUniversity of Texas MD Anderson Cancer Center, Houston, TX, USA.
Ana Patiño-GarciaDepartment of Pediatrics and Solid Tumor Division CIMA, IdiSNA, Clínica Universidad de Navarra, Pamplona, Spain.
Fernando LecandaCenter for Applied Medical Research (CIMA)-University of Navarra, IdiSNA, and CIBERONC, Pamplona, Spain.
Adrienne M FlanaganUCL Cancer Institute, Huntley Street, London WC1E 6BT, UK; Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex HA7 4LP, UK.
Fernanda AmaryRoyal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex HA7 4LP, UK.
Irene L AndrulisLitwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Jay S WunderLitwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
David M ThomasGarvan Institute of Medical Research, Darlinghurst, NSW, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Mandy L BallingerGarvan Institute of Medical Research, Darlinghurst, NSW, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Massimo SerraLaboratory of Experimental Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy; IRCCS Istituto Ortopedico Rizzoli, Osteoncology, Bone and Soft Tissue Sarcomas and Innovative Therapies, Pharmacogenomics and Pharmacogenetics Research Unit, Bologna, Italy.
Claudia HattingerLaboratory of Experimental Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy; IRCCS Istituto Ortopedico Rizzoli, Osteoncology, Bone and Soft Tissue Sarcomas and Innovative Therapies, Pharmacogenomics and Pharmacogenetics Research Unit, Bologna, Italy.
Ellen DemerathDivision of Epidemiology and Clinical Research, School of Public Health, UMN, USA.
Will JohnsonSchool of Sport, Exercise, and Health Sciences, University of Loughborough, UK.
Brenda M BirmannChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Immaculata De VivoChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Graham GilesCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
Lauren R TerasDepartment of Population Science, American Cancer Society, Atlanta, GA, USA.
Alan ArslanDepartment of Obstetrics and Gynecology, New York School of Medicine, New York, NY, USA; Department of Population Health, New York University School of Medicine, New York, NY, USA.
Roel VermeulenInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
Jeannette SampleDepartment of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA.
Neal D FreedmanDivision of Cancer Epidemiology and Genetics, NCI, NIH, Rockville, MD, USA.
Wen-Yi HuangDivision of Cancer Epidemiology and Genetics, NCI, NIH, Rockville, MD, USA.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, NCI, NIH, Rockville, MD, USA.
Sharon A SavageDivision of Cancer Epidemiology and Genetics, NCI, NIH, Rockville, MD, USA.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, NCI, NIH, Rockville, MD, USA.
Lisa MirabelloDivision of Cancer Epidemiology and Genetics, NCI, NIH, Rockville, MD, USA. Electronic address: mirabellol@nih.gov.
Center for Cancer Research · USUniversity of Minnesota · USBrigham and Women's Hospital · USGarvan Institute of Medical Research · AUIstituto Ortopedico Rizzoli · ITMount Sinai Hospital · CARoyal National Orthopaedic Hospital · GBAmerican Cancer Society · USCancer Council Victoria · AUCentro de Investigación Biomédica en Red de Cáncer · ESClinica Universidad de Navarra · ESInformation Management Services · USLoughborough University · GBNew York University · USThe University of Texas MD Anderson Cancer Center · USUtrecht University · NL

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Genetic Modifiers of Cancer RiskZIACP010142 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI MIRABELLO, LISA · 2009 to 2025
$17.1M
Cancer Epidemiology Cohort in Male Health ProfessionalsU01CA167552 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Lorelei Mucci, Walter C. Willett · 2017 to 2026
$17.0M
BIOCHEMICAL MARKERS IN THE NURSES'HEALTH STUDY COHORTR01CA049449 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HANKINSON, SUSAN E · 1989 to 2008
$11.3M
Minnesota Population Center Science and Technical CoreP2CHD041023 · NICHD · UNIVERSITY OF MINNESOTA · PI THERESA LOUISE OSYPUK · 2016 to 2026
$4.3M
Genome-Wide Association Study of Endometrial CancerR01CA134958 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI DE VIVO, IMMACULATA · 2009 to 2010
$4.3M
A prospective analysis of peripheral blood cytokines and non-Hodgkin lymphomaR01CA149445 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BIRMANN, BRENDA M · 2011 to 2015
$3.0M
Exposure to Organochlorines, EBV, and the Risk of NHLR01CA098122 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI LADEN, FRANCINE · 2003 to 2006
$2.1M
Intramural NIH HHS ZIA CP010142NCI NIH HHS P01 CA087969NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA098122NCI NIH HHS R01 CA134958NCI NIH HHS R01 CA149445NCI NIH HHS U01 CA167552NCI NIH HHS UM1 CA186107NICHD NIH HHS P2C HD041023
6 · The paper itself

Abstract

introductionSeveral studies have linked increased risk of osteosarcoma with tall stature, high birthweight, and early puberty, although evidence is inconsistent. We used genetic risk scores (GRS) based on established genetic loci for these traits and evaluated associations between genetically inferred birthweight, height, and puberty timing with osteosarcoma.

methodsUsing genotype data from two genome-wide association studies, totaling 1039 cases and 2923 controls of European ancestry, association analyses were conducted using logistic regression for each study and meta-analyzed to estimate pooled odds ratios (ORs) and 95% confidence intervals (CIs). Subgroup analyses were conducted by case diagnosis age, metastasis status, tumor location, tumor histology, and presence of a known pathogenic variant in a cancer susceptibility gene.

resultsGenetically inferred higher birthweight was associated with an increased risk of osteosarcoma (OR =1.59, 95% CI 1.07-2.38, P = 0.02). This association was strongest in cases without metastatic disease (OR =2.46, 95% CI 1.44-4.19, P = 9.5 ×10

conclusionA genetic propensity to higher birthweight was associated with increased osteosarcoma risk, suggesting that shared genetic factors or biological pathways that affect birthweight may contribute to osteosarcoma pathogenesis.

Indexed as

Birth WeightBody HeightGenome-Wide Association StudyOsteosarcomaAdolescentAdultBone NeoplasmsCase-Control StudiesChildFemaleGenetic Predisposition to DiseaseHumansMalePolymorphism, Single NucleotidePubertyRisk FactorsBirthweightGenetic risk scoreHeightOsteosarcomaPuberty timing

Identifiers

PMID37596165
PMCPMC10869637
OpenAlexW4385858564

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.