Trial reportDiabetes research and clinical practice2023
Impact of youth onset type 2 diabetes during pregnancy on microvascular and cardiac outcomes.
Jeanie B Tryggestad, Kimberly L Drews, Lisa Mele, Silva Arslanian, Steven D Chernausek, Elia N Escaname, Mitchell Geffner, Elvira Isganaitis, Jennifer Sprague, Megan M Kelsey and 1 more
Open access · greenAbstract readClinical Trial
In one paragraphTrial report in Diabetes research and clinical practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 0 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors at 8 institutions in 1 country.
Jeanie B TryggestadUniversity of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Kimberly L DrewsThe Biostatistics Center, George Washington University, Rockville, MD, USA.
Lisa MeleThe Biostatistics Center, George Washington University, Rockville, MD, USA.
Silva ArslanianUniversity of Pittsburgh, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Steven D ChernausekUniversity of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Elia N EscanameUT Health, San Antonio, Sans Antonio, TX, USA.
Mitchell GeffnerChildren's Hospital Los Angeles, Los Angeles, CA, USA.
Elvira IsganaitisJoslin Diabetes Center and Harvard Medical School, Boston, MA, USA.
Jennifer SpragueWashington University in St. Louis School of Medicine, St. Louis, MO, USA.
Megan M KelseyUniversity of Colorado Anschutz Medical Campus, Children's Hospital Colorado, Aurora, CO, USA.
TODAY Study Group
George Washington University · USUniversity of Oklahoma Health Sciences Center · USChildren's Hospital of Los Angeles · USChildren's Hospital of Pittsburgh · USJoslin Diabetes Center · USThe University of Texas Health Science Center at Houston · USUniversity of Colorado Denver · USWashington University in St. Louis · US
Funding
Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) StudyU01DK061230 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI BRAFFETT, BARBARA HALINA, ZEITLER, PHILIP S. · 2001 to 2019
$231.8MSPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5MUniversity of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LORI SUSSEL · 2020 to 2026
$10.8MPathogenesis of youth onset pre-diabetes and Type 2 diabetesR01DK111038 · NIDDK · YALE UNIVERSITY · PI CAPRIO, SONIA · 2016 to 2025
$7.0MManagement of Pediatric Type 2 Diabetes MellitusU01DK061239 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI KATZ, LORRAINE E LEVITT · 2001 to 2008
$6.9MMulti-Center Study of the Treatment of T2DM in YouthU01DK061212 · NIDDK · YALE UNIVERSITY · PI CAPRIO, SONIA · 2001 to 2008
$5.3MTreatment Alternatives in Pediatric Type 2 DiabetesU01DK061242 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI ZEITLER, PHILIP S. · 2001 to 2008
$5.1MType 2 Diabetes in Youth: Beta Cell PreservationU01DK061254 · NIDDK · CHILDREN'S HOSP PITTSBURGH/UPMC HLTH SYS · PI ARSLANIAN, SILVA A · 2001 to 2007
$4.1MNIDDK NIH HHS P30 DK036836NIDDK NIH HHS P30 DK116073NIDDK NIH HHS R01 DK111038NIDDK NIH HHS U01 DK061212NIDDK NIH HHS U01 DK061230NIDDK NIH HHS U01 DK061239NIDDK NIH HHS U01 DK061242NIDDK NIH HHS U01 DK061254
6 · The paper itselfAbstract
aimsTo examine the impact of pregnancy on microvascular and cardiovascular measures in women with youth-onset T2D.
methodsMicrovascular and cardiovascular measures were compared in in a cohort of 116 women who experienced a pregnancy of ≥ 20 weeks gestation and 291 women who did not among women in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study.
resultsCox regression models adjusted for participant characteristics at baseline including age, race/ethnicity, household income, diabetes duration, HbA1c (>6%), and BMI, demonstrated those who experienced pregnancy had 2.76 (1.38-5.49; p = 0.004) fold increased risk of hyperfiltration (eGFR ≥ 135 ml/min/1.73 m
conclusionsThese results indicate that pregnancy increases the risk of hyperfiltration in women with youth-onset T2D, but not other micro or macrovascular complications. The rates of vascular complications are very high in youth-onset T2D potentially obscuring micro- and macrovascular changes attributable to pregnancy. CLINICAL TRIAL INFORMATION: ClinicalTrials.gov numbers,NCT01364350andNCT02310724.
Indexed as
Cardiovascular DiseasesDiabetes Mellitus, Type 2AdolescentFemaleHeartHumansPregnancyRisk FactorsCardiovascularMicrovascularPregnancyYouth-Onset Type 2 Diabetes
Identifiers
PMID37595843
PMCPMC10703062
OpenAlexW4385880431
What OpenQuestion holds
Textmetadata
LicenceTDM
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