Evidence map›Paper›PMID 37595559›Full record

ArticleMolecular cell2023

FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1.

Sungyun Cho, Yujin Chun, Long He, Cuauhtemoc B Ramirez, Kripa S Ganesh, Kyungjo Jeong, Junho Song, Jin Gyu Cheong, Zhongchi Li, Jungmin Choi and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Sungyun ChoDepartment of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Yujin ChunDepartment of Microbiology and Molecular Genetics, School of Medicine, University of California Irvine, Irvine, CA, USA.
Long HeDepartment of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Cuauhtemoc B RamirezDepartment of Microbiology and Molecular Genetics, School of Medicine, University of California Irvine, Irvine, CA, USA; Department of Biological Chemistry, School of Medicine, University of California Irvine, Irvine, CA, USA.
Kripa S GaneshDepartment of Biochemistry, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Kyungjo JeongDepartment of Biomedical Sciences, College of Medicine, Korea University, Seoul, South Korea.
Junho SongDepartment of Biomedical Sciences, College of Medicine, Korea University, Seoul, South Korea.
Jin Gyu CheongDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Zhongchi LiDepartment of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Jungmin ChoiDepartment of Biomedical Sciences, College of Medicine, Korea University, Seoul, South Korea; Department of Genetics, Yale School of Medicine, Yale University, New Haven, CT, USA.
Joohwan KimDepartment of Microbiology and Molecular Genetics, School of Medicine, University of California Irvine, Irvine, CA, USA.
Nikos KoundourosDepartment of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY, USA; Meyer Cancer Center, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Fangyuan DingDepartment of Biomedical Engineering, Department of Developmental and Cell Biology, Department of Pharmaceutical Sciences, Center for Synthetic Biology, and Center for Neural Circuit Mapping, University of California Irvine, Irvine, CA, USA; Center for Complex Biological Systems and Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, USA.
Noah DephoureMeyer Cancer Center, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Cholsoon JangDepartment of Biological Chemistry, School of Medicine, University of California Irvine, Irvine, CA, USA; Center for Complex Biological Systems and Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, USA; Center for Epigenetics and Metabolism, University of California Irvine, Irvine, CA, USA.
John BlenisDepartment of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY, USA; Meyer Cancer Center, Weill Cornell Medicine, Cornell University, New York, NY, USA. Electronic address: job2064@med.cornell.edu.
Gina LeeDepartment of Microbiology and Molecular Genetics, School of Medicine, University of California Irvine, Irvine, CA, USA; Center for Complex Biological Systems and Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, USA; Center for Epigenetics and Metabolism, University of California Irvine, Irvine, CA, USA. Electronic address: ginalee@uci.edu.
Cornell University · USUniversity of California, Irvine · USKorea University · KR

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
MINORITY BIOMEDICAL RESEARCHERS PROGRAMR25GM055246 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI MOTA-BRAVO, LUIS M · 1996 to 2022
$15.3M
SIGNAL TRANSDUCTION TO PP70 S6KR01GM051405 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI BLENIS, JOHN · 1995 to 2023
$14.0M
ONCOGENIC REGULATION OF S6 PROTEIN KINASE &CELL GROWTHR01CA046595 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI JOHN BLENIS · 1988 to 2026
$10.6M
CARCINOGENESIST32CA009054 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI EDINGER, AIMEE L, FRUMAN, DAVID ALEXANDER · 1985 to 2025
$8.6M
Universally-applicable RNA mapping at subcellular and single-base resolutionDP2GM149554 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DING, FANGYUAN · 2022 to 2025
$2.3M
Elucidating dietary fructose and alcohol interactions during liver cancer developmentR01AA029124 · NIAAA · UNIVERSITY OF CALIFORNIA-IRVINE · PI JANG, CHOLSOON · 2021 to 2025
$2.0M
Elucidating the regulation of RNA methylation by mTOR signaling in cancerK22CA234399 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LEE, GINA · 2022 to 2023
$440k
NCI NIH HHS K22 CA234399NCI NIH HHS P30 CA062203NCI NIH HHS R01 CA046595NCI NIH HHS T32 CA009054NIAAA NIH HHS R01 AA029124NIGMS NIH HHS DP2 GM149554NIGMS NIH HHS R01 GM051405NIGMS NIH HHS R25 GM055246
6 · The paper itself

Abstract

The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth that stimulates macromolecule synthesis through transcription, RNA processing, and post-translational modification of metabolic enzymes. However, the mechanisms of how mTORC1 orchestrates multiple steps of gene expression programs remain unclear. Here, we identify family with sequence similarity 120A (FAM120A) as a transcription co-activator that couples transcription and splicing of de novo lipid synthesis enzymes downstream of mTORC1-serine/arginine-rich protein kinase 2 (SRPK2) signaling. The mTORC1-activated SRPK2 phosphorylates splicing factor serine/arginine-rich splicing factor 1 (SRSF1), enhancing its binding to FAM120A. FAM120A directly interacts with a lipogenic transcription factor SREBP1 at active promoters, thereby bridging the newly transcribed lipogenic genes from RNA polymerase II to the SRSF1 and U1-70K-containing RNA-splicing machinery. This mTORC1-regulated, multi-protein complex promotes efficient splicing and stability of lipogenic transcripts, resulting in fatty acid synthesis and cancer cell proliferation. These results elucidate FAM120A as a critical transcription co-factor that connects mTORC1-dependent gene regulation programs for anabolic cell growth.

Indexed as

ArginineLipogenesisSterol Regulatory Element Binding Protein 1HumansMechanistic Target of Rapamycin Complex 1RNA-Binding ProteinsRNA Splicing FactorsSterol Regulatory Element Binding ProteinsArginineFAM120A protein, humanMechanistic Target of Rapamycin Complex 1RNA-Binding ProteinsRNA Splicing FactorsSterol Regulatory Element Binding Protein 1Sterol Regulatory Element Binding ProteinsFAM120Alipid metabolismmTOR signalingRNA splicingRNA stabilitySREBPSRPK2SRSF1

Identifiers

PMID37595559
PMCPMC10494788
OpenAlexW4385949178

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.