Evidence map›Paper›PMID 37595481›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2023

Characteristics of ictal thalamic EEG in pediatric-onset neocortical focal epilepsy.

Benjamin Edmonds, Makoto Miyakoshi, Luigi Gianmaria Remore, Samuel Ahn, H Westley Phillips, Atsuro Daida, Noriko Salamon, Ausaf Bari, Raman Sankar, Joyce H Matsumoto and 2 more

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In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Short-Term Modulation of Epileptic Network with Low-Frequency Thalamic Stimulation.medRxiv : the preprint server for health sciences · 2025
    Article
  5. Fast ripple band high-frequency activity associated with thalamic sleep spindles in pediatric epilepsy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Benjamin EdmondsDivision of Pediatric Neurology, Department of Pediatrics, UCLA Mattel Children's Hospital, David Geffen School of Medicine, Los Angeles, CA, USA. Electronic address: benjamin.edmonds@seattlechildrens.org.
Makoto MiyakoshiDivision of Child and Adolescent Psychiatry, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Swartz Center for Computational Neuroscience, Institute for Neural Computation, University of California San Diego, UCSD Medical Center, San Diego, CA, USA. Electronic address: Makoto.Miyakoshi@cchmc.org.
Luigi Gianmaria RemoreDepartment of Neurosurgery, UCLA Medical Center, David Geffen School of Medicine, Los Angeles, CA, USA.
Samuel AhnDivision of Pediatric Neurology, Department of Pediatrics, UCLA Mattel Children's Hospital, David Geffen School of Medicine, Los Angeles, CA, USA.
H Westley PhillipsDepartment of Neurosurgery, UCLA Medical Center, David Geffen School of Medicine, Los Angeles, CA, USA.
Atsuro DaidaDivision of Pediatric Neurology, Department of Pediatrics, UCLA Mattel Children's Hospital, David Geffen School of Medicine, Los Angeles, CA, USA.
Noriko SalamonDepartment of Radiological Sciences, University of California, Los Angeles, CA, USA.
Ausaf BariDepartment of Neurosurgery, UCLA Medical Center, David Geffen School of Medicine, Los Angeles, CA, USA.
Raman SankarDivision of Pediatric Neurology, Department of Pediatrics, UCLA Mattel Children's Hospital, David Geffen School of Medicine, Los Angeles, CA, USA; The UCLA Children's Discovery and Innovation Institute, Los Angeles, CA, USA.
Joyce H MatsumotoDivision of Pediatric Neurology, Department of Pediatrics, UCLA Mattel Children's Hospital, David Geffen School of Medicine, Los Angeles, CA, USA.
Aria FallahDepartment of Neurosurgery, UCLA Medical Center, David Geffen School of Medicine, Los Angeles, CA, USA.
Hiroki NariaiDivision of Pediatric Neurology, Department of Pediatrics, UCLA Mattel Children's Hospital, David Geffen School of Medicine, Los Angeles, CA, USA; The UCLA Children's Discovery and Innovation Institute, Los Angeles, CA, USA. Electronic address: hnariai@mednet.ucla.edu.

Funding

EEGLAB: Software for Analysis of Human Brain DynamicsR01NS047293 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Arnaud Delorme, Scott Makeig · 2004 to 2026
$10.2M
Refining neurophysiological biomarkers of epilepsy using deep learning to guide pediatric epilepsy surgeryK23NS128318 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Hiroki Nariai · 2023 to 2026
$968k
NINDS NIH HHS K23 NS128318NINDS NIH HHS R01 NS047293
6 · The paper itself

Abstract

objectiveTo characterize ictal EEG change in the centromedian (CM) and anterior nucleus (AN) of the thalamus, using stereoelectroencephalography (SEEG) recordings.

methodsForty habitual seizures were analyzed in nine patients with pediatric-onset neocortical drug-resistant epilepsy who underwent SEEG (age 2-25 y) with thalamic coverage. Both visual and quantitative analysis was used to evaluate ictal EEG signal in the cortex and thalamus. The amplitude and cortico-thalamic latencies of broadband frequencies at ictal onset were measured.

resultsVisual analysis demonstrated consistent detection of ictal EEG changes in both the CM nucleus and AN nucleus with latency to thalamic ictal EEG changes of less than 400 ms in 95% of seizures, with low-voltage fast activity being the most common ictal pattern. Quantitative broadband amplitude analysis showed consistent power changes across the frequency bands, corresponding to ictal EEG onset, while while ictal EEG latency was variable from -18.0 seconds to 13.2 seconds. There was no significant difference between detection of CM and AN ictal activity on visual or amplitude analysis. Four patients with subsequent thalamic responsive neurostimulation (RNS) demonstrated ictal EEG changes consistent with SEEG findings.

conclusionsIctal EEG changes were consistently seen at the CM and AN of the thalamus during neocortical seizures. SIGNIFICANCE: It may be feasible to use a closed-loop system in the thalamus to detect and modulate seizure activity for neocortical epilepsy.

Indexed as

Epilepsies, PartialEpilepsyNeocortexAdolescentAdultChildChild, PreschoolElectroencephalographyHumansSeizuresThalamusYoung AdultDrug-resistant epilepsyEpilepsy surgeryNeurostimulationRNSThalamus

Identifiers

PMID37595481
PMCPMC10529874

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.